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• W2948284511 endingPage "876" @default.
• W2948284511 startingPage "860" @default.
• W2948284511 abstract "Organoids form through self-organization processes in which initially homogeneous populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern formation and morphogenesis, though the processes controlling this are poorly characterized. While these in vitro self-organized tissues far exceed the microscopic and functional complexity obtained by current tissue engineering technologies, they are non-physiological in shape and size and have limited function and lifespan. Here, we discuss how engineering efforts for guiding stem-cell-based development at multiple stages can form the basis for the assembly of highly complex and rationally designed self-organizing multicellular systems with increased robustness and physiological relevance." @default.
• W2948284511 created "2019-06-14" @default.
• W2948284511 creator A5004455575 @default.
• W2948284511 creator A5070364238 @default.
• W2948284511 date "2019-06-01" @default.
• W2948284511 modified "2023-10-14" @default.
• W2948284511 title "Engineering Stem Cell Self-organization to Build Better Organoids" @default.
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