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- W2948303782 abstract "Abstract Patient-derived isolates of the opportunistic pathogen Pseudomonas aeruginosa are frequently resistant to antibiotics due to the presence of sequence variants in resistance-associated genes. However, the frequency of antibiotic resistance and of resistance-associated sequence variants in environmental isolates of P. aeruginosa has not been well studied. Antimicrobial susceptibility testing (ciprofloxacin, ceftazidime, meropenem, tobramycin) of environmental (n=50) and cystic fibrosis (n=42) P. aeruginosa isolates was carried out. Following whole genome sequencing of all isolates, twenty-five resistance-associated genes were analysed for the presence of likely function-altering sequence variants. Environmental isolates were susceptible to all antibiotics with one exception, whereas patient-derived isolates had significant frequencies of resistance to each antibiotic and a greater number of likely resistance-associated genetic variants. These findings indicate that the natural environment does not act as a reservoir of antibiotic-resistant P. aeruginosa , supporting a model in which antibiotic susceptible environmental bacteria infect patients and develop resistance during infection. Author Contributions" @default.
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- W2948303782 date "2019-06-07" @default.
- W2948303782 modified "2023-09-22" @default.
- W2948303782 title "Genomic and phenotypic comparison of environmental and patient-derived isolates ofPseudomonas aeruginosasuggest that antimicrobial resistance is rare within the environment" @default.
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- W2948303782 doi "https://doi.org/10.1101/663674" @default.
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