FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948328305> ?p ?o ?g. }

• W2948328305 endingPage "428" @default.
• W2948328305 startingPage "418" @default.
• W2948328305 abstract "It has long been appreciated that highly autoreactive BCRs are actively removed from the developing B cell repertoire by Ag-dependent receptor editing and deletion. However, there is persistent debate about whether mild autoreactivity is simply tolerated or positively selected into the mature B cell repertoire as well as at what stage, to what extent, under what conditions, and into which compartments this occurs. In this study, we describe two minor, trackable populations of B cells in B1-8i Ig transgenic mice that express the VH186.2 H chain and recognize a common foreign Ag (the hapten 4-hydroxy-3-nitrophenylacetyl) but differ in L chain expression. We use the Nur77-eGFP reporter of BCR signaling to define their reactivity toward endogenous Ags. The less autoreactive of these two populations is strongly counterselected during the development of mature B1a, follicular, and marginal zone B cells. By genetically manipulating the strength of BCR signal transduction via the titration of surface CD45 expression, we demonstrate that this B cell population is not negatively selected but instead displays characteristics of impaired positive selection. We demonstrate that mild self-reactivity improves the developmental fitness of B cell clones in the context of a diverse population of B cells, and positive selection by endogenous Ags shapes the mature B cell repertoire." @default.
• W2948328305 created "2019-06-14" @default.
• W2948328305 creator A5023603694 @default.
• W2948328305 creator A5036418672 @default.
• W2948328305 creator A5039726987 @default.
• W2948328305 creator A5049550450 @default.
• W2948328305 creator A5057532755 @default.
• W2948328305 creator A5072976500 @default.
• W2948328305 date "2019-07-15" @default.
• W2948328305 modified "2023-09-24" @default.
• W2948328305 title "Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens" @default.
• W2948328305 cites W1686167184 @default.
• W2948328305 cites W1966949480 @default.
• W2948328305 cites W1971308487 @default.
• W2948328305 cites W1973540902 @default.
• W2948328305 cites W1993214965 @default.
• W2948328305 cites W1993302019 @default.
• W2948328305 cites W2003603592 @default.
• W2948328305 cites W2007886976 @default.
• W2948328305 cites W2008073080 @default.
• W2948328305 cites W2018243210 @default.
• W2948328305 cites W2024852380 @default.
• W2948328305 cites W2036859226 @default.
• W2948328305 cites W2043186109 @default.
• W2948328305 cites W2046421048 @default.
• W2948328305 cites W2046696423 @default.
• W2948328305 cites W2048036824 @default.
• W2948328305 cites W2048799673 @default.
• W2948328305 cites W2054515677 @default.
• W2948328305 cites W2056807976 @default.
• W2948328305 cites W2062198339 @default.
• W2948328305 cites W2063825367 @default.
• W2948328305 cites W2070679465 @default.
• W2948328305 cites W2075130635 @default.
• W2948328305 cites W2076198413 @default.
• W2948328305 cites W2078845104 @default.
• W2948328305 cites W2079232338 @default.
• W2948328305 cites W2081064697 @default.
• W2948328305 cites W2095903025 @default.
• W2948328305 cites W2097604076 @default.
• W2948328305 cites W2110311209 @default.
• W2948328305 cites W2114876320 @default.
• W2948328305 cites W2116370657 @default.
• W2948328305 cites W2125748493 @default.
• W2948328305 cites W2134749957 @default.
• W2948328305 cites W2135029910 @default.
• W2948328305 cites W2149578241 @default.
• W2948328305 cites W2154424072 @default.
• W2948328305 cites W2158547214 @default.
• W2948328305 cites W2169961384 @default.
• W2948328305 cites W2342697778 @default.
• W2948328305 cites W2412441525 @default.
• W2948328305 cites W2421876019 @default.
• W2948328305 cites W2605350170 @default.
• W2948328305 cites W2765526553 @default.
• W2948328305 cites W2791186555 @default.
• W2948328305 cites W2794856142 @default.
• W2948328305 cites W2796765284 @default.
• W2948328305 cites W2914185840 @default.
• W2948328305 doi "https://doi.org/10.4049/jimmunol.1900175" @default.
• W2948328305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6668988" @default.
• W2948328305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31167773" @default.
• W2948328305 hasPublicationYear "2019" @default.
• W2948328305 type Work @default.
• W2948328305 sameAs 2948328305 @default.
• W2948328305 citedByCount "18" @default.
• W2948328305 countsByYear W29483283052019 @default.
• W2948328305 countsByYear W29483283052020 @default.
• W2948328305 countsByYear W29483283052021 @default.
• W2948328305 countsByYear W29483283052022 @default.
• W2948328305 countsByYear W29483283052023 @default.
• W2948328305 crossrefType "journal-article" @default.
• W2948328305 hasAuthorship W2948328305A5023603694 @default.
• W2948328305 hasAuthorship W2948328305A5036418672 @default.
• W2948328305 hasAuthorship W2948328305A5039726987 @default.
• W2948328305 hasAuthorship W2948328305A5049550450 @default.
• W2948328305 hasAuthorship W2948328305A5057532755 @default.
• W2948328305 hasAuthorship W2948328305A5072976500 @default.
• W2948328305 hasBestOaLocation W29483283051 @default.
• W2948328305 hasConcept C102230213 @default.
• W2948328305 hasConcept C104317684 @default.
• W2948328305 hasConcept C121332964 @default.
• W2948328305 hasConcept C134018914 @default.
• W2948328305 hasConcept C141231307 @default.
• W2948328305 hasConcept C144024400 @default.
• W2948328305 hasConcept C147483822 @default.
• W2948328305 hasConcept C149923435 @default.
• W2948328305 hasConcept C151730666 @default.
• W2948328305 hasConcept C159654299 @default.
• W2948328305 hasConcept C16613235 @default.
• W2948328305 hasConcept C170493617 @default.
• W2948328305 hasConcept C195616568 @default.
• W2948328305 hasConcept C203014093 @default.
• W2948328305 hasConcept C24890656 @default.
• W2948328305 hasConcept C2778453870 @default.
• W2948328305 hasConcept C2778473898 @default.
• W2948328305 hasConcept C2779343474 @default.
• W2948328305 hasConcept C2779921676 @default.

• next