FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948341381> ?p ?o ?g. }

• W2948341381 endingPage "4435" @default.
• W2948341381 startingPage "4427" @default.
• W2948341381 abstract "Background: Oral squamous cell carcinoma (OSCC) is one of the most common cancers, with high metastasis and mortality. Licochalcone A (LCA) is a chalconoid from the root of Glycyrrhiza inflata, which has anti-tumor, anti-inflammatory, anti-angiogenesis effects in many cancers. However, the mechanism that underlies LCA regulating cell proliferation, migration, and invasion in OSCC remains poorly understood. Methods: LY294002 or insulin-like growth factor 1 (IGF-1) were used to block or stimulate the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway in OSCC cells. Cell proliferation was investigated by MTT assay and proliferating cell nuclear antigen (PCNA) protein level using Western blot. The expression of metastasis-related protein was detected via Western blot. Cell migration and invasion abilities were evaluated by trans-well assay. A murine xenograft model of OSCC was established to investigate the anti-tumor effect of LCA in vivo. Results: Treatment of LCA inhibited cell proliferation in SCC4 and CAL-27 cells. Moreover, PI3K/AKT signaling was blocked by LY294002, and activated by IGF-1. LCA could suppress proliferation, migration, and invasion of OSCC cells, which was similar to the treatment of LY294002. In addition, LCA decreased IGF-1-induced OSCC progression. In a murine xenograft model, LCA treatment protected against tumor growth and metastasis in vivo. Conclusions: LCA might inhibit cell proliferation, migration, and invasion through regulating the PI3K/AKT pathway in OSCC, developing a potential chemotherapeutic agent for OSCC." @default.
• W2948341381 created "2019-06-14" @default.
• W2948341381 creator A5018370210 @default.
• W2948341381 creator A5018623969 @default.
• W2948341381 creator A5031104596 @default.
• W2948341381 creator A5036744042 @default.
• W2948341381 date "2019-06-01" @default.
• W2948341381 modified "2023-09-25" @default.
• W2948341381 title "<p>Licochalcone A inhibits cell proliferation, migration, and invasion through regulating the PI3K/AKT signaling pathway in oral squamous cell carcinoma</p>" @default.
• W2948341381 cites W1992477322 @default.
• W2948341381 cites W2010485702 @default.
• W2948341381 cites W2017091837 @default.
• W2948341381 cites W2060293987 @default.
• W2948341381 cites W2073433258 @default.
• W2948341381 cites W2100516071 @default.
• W2948341381 cites W2122155691 @default.
• W2948341381 cites W2140416086 @default.
• W2948341381 cites W2305786969 @default.
• W2948341381 cites W2348693795 @default.
• W2948341381 cites W2558423424 @default.
• W2948341381 cites W264423964 @default.
• W2948341381 cites W2730407871 @default.
• W2948341381 cites W2745647838 @default.
• W2948341381 cites W2755794599 @default.
• W2948341381 cites W2756772951 @default.
• W2948341381 cites W2761376533 @default.
• W2948341381 cites W2768188655 @default.
• W2948341381 cites W2769439470 @default.
• W2948341381 cites W2790312388 @default.
• W2948341381 cites W2792376822 @default.
• W2948341381 cites W2792756356 @default.
• W2948341381 cites W2793037725 @default.
• W2948341381 cites W2793963166 @default.
• W2948341381 cites W2799960571 @default.
• W2948341381 cites W2800097232 @default.
• W2948341381 cites W2806869833 @default.
• W2948341381 cites W2836355494 @default.
• W2948341381 cites W2881437683 @default.
• W2948341381 cites W2884348297 @default.
• W2948341381 cites W2884946361 @default.
• W2948341381 cites W2885827642 @default.
• W2948341381 cites W2887134879 @default.
• W2948341381 cites W2887930512 @default.
• W2948341381 cites W2888426499 @default.
• W2948341381 cites W2888686839 @default.
• W2948341381 cites W2995940451 @default.
• W2948341381 doi "https://doi.org/10.2147/ott.s201728" @default.
• W2948341381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6556467" @default.
• W2948341381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31239711" @default.
• W2948341381 hasPublicationYear "2019" @default.
• W2948341381 type Work @default.
• W2948341381 sameAs 2948341381 @default.
• W2948341381 citedByCount "21" @default.
• W2948341381 countsByYear W29483413812019 @default.
• W2948341381 countsByYear W29483413812020 @default.
• W2948341381 countsByYear W29483413812021 @default.
• W2948341381 countsByYear W29483413812022 @default.
• W2948341381 countsByYear W29483413812023 @default.
• W2948341381 crossrefType "journal-article" @default.
• W2948341381 hasAuthorship W2948341381A5018370210 @default.
• W2948341381 hasAuthorship W2948341381A5018623969 @default.
• W2948341381 hasAuthorship W2948341381A5031104596 @default.
• W2948341381 hasAuthorship W2948341381A5036744042 @default.
• W2948341381 hasBestOaLocation W29483413811 @default.
• W2948341381 hasConcept C121608353 @default.
• W2948341381 hasConcept C126322002 @default.
• W2948341381 hasConcept C137738243 @default.
• W2948341381 hasConcept C1491633281 @default.
• W2948341381 hasConcept C185592680 @default.
• W2948341381 hasConcept C2776912716 @default.
• W2948341381 hasConcept C2779013556 @default.
• W2948341381 hasConcept C2780394083 @default.
• W2948341381 hasConcept C34688535 @default.
• W2948341381 hasConcept C502942594 @default.
• W2948341381 hasConcept C55493867 @default.
• W2948341381 hasConcept C62112901 @default.
• W2948341381 hasConcept C62478195 @default.
• W2948341381 hasConcept C71924100 @default.
• W2948341381 hasConcept C75217442 @default.
• W2948341381 hasConcept C86554907 @default.
• W2948341381 hasConcept C86803240 @default.
• W2948341381 hasConcept C95444343 @default.
• W2948341381 hasConceptScore W2948341381C121608353 @default.
• W2948341381 hasConceptScore W2948341381C126322002 @default.
• W2948341381 hasConceptScore W2948341381C137738243 @default.
• W2948341381 hasConceptScore W2948341381C1491633281 @default.
• W2948341381 hasConceptScore W2948341381C185592680 @default.
• W2948341381 hasConceptScore W2948341381C2776912716 @default.
• W2948341381 hasConceptScore W2948341381C2779013556 @default.
• W2948341381 hasConceptScore W2948341381C2780394083 @default.
• W2948341381 hasConceptScore W2948341381C34688535 @default.
• W2948341381 hasConceptScore W2948341381C502942594 @default.
• W2948341381 hasConceptScore W2948341381C55493867 @default.
• W2948341381 hasConceptScore W2948341381C62112901 @default.
• W2948341381 hasConceptScore W2948341381C62478195 @default.
• W2948341381 hasConceptScore W2948341381C71924100 @default.
• W2948341381 hasConceptScore W2948341381C75217442 @default.
• W2948341381 hasConceptScore W2948341381C86554907 @default.

• next