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• W2948382142 endingPage "2297" @default.
• W2948382142 startingPage "2297" @default.
• W2948382142 abstract "Oligonucleotides are key compounds widely used for research, diagnostics, and therapeutics. The rapid increase in oligonucleotide-based applications, together with the progress in nucleic acids research, has led to the design of nucleotide analogs that, when part of these oligomers, enhance their efficiency, bioavailability, or stability. One of the most useful nucleotide analogs is the first-generation bridged nucleic acids (BNA), also known as locked nucleic acids (LNA), which were used in combination with ribonucleotides, deoxyribonucleotides, or other analogs to construct oligomers with diverse applications. However, there is still room to improve their efficiency, bioavailability, stability, and, importantly, toxicity. A second-generation BNA, BNANC (2'-O,4'-aminoethylene bridged nucleic acid), has been recently made available. Oligomers containing these analogs not only showed less toxicity when compared to LNA-containing compounds but, in some cases, also exhibited higher specificity. Although there are still few applications where BNANC-containing compounds have been researched, the promising results warrant more effort in incorporating these analogs for other applications. Furthermore, newer BNA compounds will be introduced in the near future, offering great hope to oligonucleotide-based fields of research and applications." @default.
• W2948382142 created "2019-06-14" @default.
• W2948382142 creator A5005522906 @default.
• W2948382142 creator A5020519655 @default.
• W2948382142 creator A5020802740 @default.
• W2948382142 date "2019-06-21" @default.
• W2948382142 modified "2023-10-13" @default.
• W2948382142 title "Bridged Nucleic Acids Reloaded" @default.
• W2948382142 cites W1563786107 @default.
• W2948382142 cites W1579015871 @default.
• W2948382142 cites W1579469490 @default.
• W2948382142 cites W169430549 @default.
• W2948382142 cites W1788559458 @default.
• W2948382142 cites W1966230361 @default.
• W2948382142 cites W1966880264 @default.
• W2948382142 cites W1966954379 @default.
• W2948382142 cites W1971668951 @default.
• W2948382142 cites W1975350316 @default.
• W2948382142 cites W1976033874 @default.
• W2948382142 cites W1976325953 @default.
• W2948382142 cites W1976526513 @default.
• W2948382142 cites W1976691226 @default.
• W2948382142 cites W1979393045 @default.
• W2948382142 cites W1981160614 @default.
• W2948382142 cites W1984561186 @default.
• W2948382142 cites W1987486422 @default.
• W2948382142 cites W1987578671 @default.
• W2948382142 cites W1992972857 @default.
• W2948382142 cites W1993362540 @default.
• W2948382142 cites W1998001208 @default.
• W2948382142 cites W1998666145 @default.
• W2948382142 cites W1999667822 @default.
• W2948382142 cites W2000277299 @default.
• W2948382142 cites W2003212416 @default.
• W2948382142 cites W2003986119 @default.
• W2948382142 cites W2004130102 @default.
• W2948382142 cites W2005802306 @default.
• W2948382142 cites W2005880821 @default.
• W2948382142 cites W2008705635 @default.
• W2948382142 cites W2011857098 @default.
• W2948382142 cites W2013723932 @default.
• W2948382142 cites W2019670881 @default.
• W2948382142 cites W2027658098 @default.
• W2948382142 cites W2029409791 @default.
• W2948382142 cites W2030120319 @default.
• W2948382142 cites W2031631844 @default.
• W2948382142 cites W2032661725 @default.
• W2948382142 cites W2034180036 @default.
• W2948382142 cites W2036284756 @default.
• W2948382142 cites W2038332844 @default.
• W2948382142 cites W2039705224 @default.
• W2948382142 cites W2040612932 @default.
• W2948382142 cites W2041375942 @default.
• W2948382142 cites W2041665769 @default.
• W2948382142 cites W2043985464 @default.
• W2948382142 cites W2045397431 @default.
• W2948382142 cites W2045435533 @default.
• W2948382142 cites W2045587009 @default.
• W2948382142 cites W2045995934 @default.
• W2948382142 cites W2047575731 @default.
• W2948382142 cites W2047935905 @default.
• W2948382142 cites W2048359227 @default.
• W2948382142 cites W2050909344 @default.
• W2948382142 cites W2052451894 @default.
• W2948382142 cites W2052942970 @default.
• W2948382142 cites W2053968609 @default.
• W2948382142 cites W2054610237 @default.
• W2948382142 cites W2057711152 @default.
• W2948382142 cites W2061015821 @default.
• W2948382142 cites W2063024922 @default.
• W2948382142 cites W2064815984 @default.
• W2948382142 cites W2066353862 @default.
• W2948382142 cites W2066859359 @default.
• W2948382142 cites W2067685971 @default.
• W2948382142 cites W2070807618 @default.
• W2948382142 cites W2071209050 @default.
• W2948382142 cites W2077546113 @default.
• W2948382142 cites W2080036688 @default.
• W2948382142 cites W2080853945 @default.
• W2948382142 cites W2086223988 @default.
• W2948382142 cites W2088707712 @default.
• W2948382142 cites W2089589904 @default.
• W2948382142 cites W2091559790 @default.
• W2948382142 cites W2098889266 @default.
• W2948382142 cites W2100138380 @default.
• W2948382142 cites W2100181290 @default.
• W2948382142 cites W2104525153 @default.
• W2948382142 cites W2104713605 @default.
• W2948382142 cites W2109436341 @default.
• W2948382142 cites W2110045185 @default.
• W2948382142 cites W2110058183 @default.
• W2948382142 cites W2110083155 @default.
• W2948382142 cites W2110424949 @default.
• W2948382142 cites W2112238907 @default.
• W2948382142 cites W2113468928 @default.
• W2948382142 cites W2115552263 @default.
• W2948382142 cites W2118105142 @default.
• W2948382142 cites W2121148907 @default.

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