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• W2948393371 endingPage "3580" @default.
• W2948393371 startingPage "3567" @default.
• W2948393371 abstract "Obesity is a medical and sociological problem of great importance due to the high percentage of people affected and the important health consequences that it involves. Most cases of obesity are related to an inadequate diet, rich in fats, which could lead to changes in the patient's oxygenic metabolism. That is why this study has been proposed to evaluate how some aspects of oxygenic metabolism are affected in a nutritional experimental model, with a controlled hyperlipidic liquid diet based on olive oil, and the effect of the antioxidant vitamin C on these conditions. Wistar rats were divided into four groups which received a control and hyperlipidic liquid diet for 30 days, with or without a vitamin C supplement (CO, COC, HO and HOC). First of all the body and fat tissue development was measured in the four groups. Our results showed that the excessive intake of nutritional and healthy fat such as olive oil did not prevent the appearance of obesity and the supplementation with vitamin C did not have a protective effect on body and fat development. The study of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in total liver, liver cytosol, abdominal white fat, brown fat and blood cells showed that vitamin C could have different selectivities and affinities for different enzymes and compartments/tissues of the body. Finally, the effect of vitamin C on various metabolic parameters (glucose, pyruvate, lactate, LDH, ATP, acetoacetate and beta-hydroxybutyrate) provided positive protection against oxidative stress especially under hyperlipidic conditions. All things considered, the present study concludes that vitamin C treatment could protect Wistar rats from the oxidative stress impairment induced by obesity generated by an excessive intake of fats." @default.
• W2948393371 created "2019-06-14" @default.
• W2948393371 creator A5006340232 @default.
• W2948393371 creator A5012262898 @default.
• W2948393371 creator A5016299753 @default.
• W2948393371 creator A5073370655 @default.
• W2948393371 creator A5074574287 @default.
• W2948393371 date "2019-01-01" @default.
• W2948393371 modified "2023-10-12" @default.
• W2948393371 title "Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C" @default.
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