Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948402667> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2948402667 endingPage "LB" @default.
- W2948402667 startingPage "297" @default.
- W2948402667 abstract "Homozygous loss-of-function ANGPTL3variants are associated with familial combined hypolipidemia, suggesting the dual LPL/EL inhibitor is a promising target for treating atherogenic dyslipidemia. However, nothing is known regarding the dietary regulation of ANGPTL3, including effects of dietary sugar or n-3 fatty acids. We investigated plasma ANGPTL3 concentrations in a rhesus macaque model of high sugar diet-induced dyslipidemia. Animals provided fructose beverages (300 kcal/d) rapidly gain weight (∼10%) and develop insulin resistance and fasting hypertriglyceridemia within 1 month. Fasting plasma ANGPTL3 concentrations increased by 30-40% with fructose consumption after 1 and 3 months (mean±SD in ng/ml; baseline, 60.6±17.4; 1 month, 83.1±25.3; 3 months, 76.9±23.2; both p<0.001 vs. baseline, n=59). Fish oil supplementation (4 g/d) prevents fructose-induced dyslipidemia and completely prevented the increases of ANGPTL3 (-3% vs. +33% over 6 months, p<0.05). Regression modeling to identify lipid/lipoprotein parameters (TG, TC, HDL-C, LDL-C, VLDL-C, APOA1, APOB, APOC3, APOE) explaining variation in ANGPTL3 levels indicated strong correlations with APOC3 at baseline (p=0.002), and APOC3 and APOE after 3 months of fructose (both p<0.05). Regression modeling also examined whether changes (?) of APOC3, APOE, and ANGPTL3 predict ?TG, explaining 41% of variation after 1 month. (R2=0.41, p<0.001). ?APOC3 (B=0.588, p<0.001) and ?ANGPTL3 (B=0.292, p<0.05) were significant predictors in the model. After 3 months, modeling explained 36% of ∆TG (R2=0.36, p<0.001), with all variables contributing significantly (?APOC3, B=0.616, p<0.001; ?ANGPTL3, B=0.245, p<0.05; ?APOE, B= -0.281, p<0.05). Modeling predicted variation of ∆TG before and during fructose consumption (R2=0.294, p=0.033 at baseline; R2=0.438, p<0.001 at 3 months)." @default.
- W2948402667 created "2019-06-14" @default.
- W2948402667 creator A5034829692 @default.
- W2948402667 creator A5056635157 @default.
- W2948402667 creator A5065673214 @default.
- W2948402667 creator A5081546127 @default.
- W2948402667 date "2019-06-01" @default.
- W2948402667 modified "2023-09-25" @default.
- W2948402667 title "297-LB: Dietary Fructose Increases Plasma Angiopoietin-Like Protein-3 Concentrations in Rhesus Macaques: Prevention with Fish Oil Supplementation" @default.
- W2948402667 doi "https://doi.org/10.2337/db19-297-lb" @default.
- W2948402667 hasPublicationYear "2019" @default.
- W2948402667 type Work @default.
- W2948402667 sameAs 2948402667 @default.
- W2948402667 citedByCount "0" @default.
- W2948402667 crossrefType "journal-article" @default.
- W2948402667 hasAuthorship W2948402667A5034829692 @default.
- W2948402667 hasAuthorship W2948402667A5056635157 @default.
- W2948402667 hasAuthorship W2948402667A5065673214 @default.
- W2948402667 hasAuthorship W2948402667A5081546127 @default.
- W2948402667 hasConcept C126322002 @default.
- W2948402667 hasConcept C134018914 @default.
- W2948402667 hasConcept C185592680 @default.
- W2948402667 hasConcept C2776919658 @default.
- W2948402667 hasConcept C2776970464 @default.
- W2948402667 hasConcept C2777391703 @default.
- W2948402667 hasConcept C2778096610 @default.
- W2948402667 hasConcept C2778163477 @default.
- W2948402667 hasConcept C2778913445 @default.
- W2948402667 hasConcept C2779946292 @default.
- W2948402667 hasConcept C2909208804 @default.
- W2948402667 hasConcept C505870484 @default.
- W2948402667 hasConcept C511355011 @default.
- W2948402667 hasConcept C55493867 @default.
- W2948402667 hasConcept C62746215 @default.
- W2948402667 hasConcept C71924100 @default.
- W2948402667 hasConcept C86803240 @default.
- W2948402667 hasConceptScore W2948402667C126322002 @default.
- W2948402667 hasConceptScore W2948402667C134018914 @default.
- W2948402667 hasConceptScore W2948402667C185592680 @default.
- W2948402667 hasConceptScore W2948402667C2776919658 @default.
- W2948402667 hasConceptScore W2948402667C2776970464 @default.
- W2948402667 hasConceptScore W2948402667C2777391703 @default.
- W2948402667 hasConceptScore W2948402667C2778096610 @default.
- W2948402667 hasConceptScore W2948402667C2778163477 @default.
- W2948402667 hasConceptScore W2948402667C2778913445 @default.
- W2948402667 hasConceptScore W2948402667C2779946292 @default.
- W2948402667 hasConceptScore W2948402667C2909208804 @default.
- W2948402667 hasConceptScore W2948402667C505870484 @default.
- W2948402667 hasConceptScore W2948402667C511355011 @default.
- W2948402667 hasConceptScore W2948402667C55493867 @default.
- W2948402667 hasConceptScore W2948402667C62746215 @default.
- W2948402667 hasConceptScore W2948402667C71924100 @default.
- W2948402667 hasConceptScore W2948402667C86803240 @default.
- W2948402667 hasIssue "Supplement 1" @default.
- W2948402667 hasLocation W29484026671 @default.
- W2948402667 hasOpenAccess W2948402667 @default.
- W2948402667 hasPrimaryLocation W29484026671 @default.
- W2948402667 hasRelatedWork W1997338705 @default.
- W2948402667 hasRelatedWork W2028937980 @default.
- W2948402667 hasRelatedWork W2037584498 @default.
- W2948402667 hasRelatedWork W2039250890 @default.
- W2948402667 hasRelatedWork W2099385407 @default.
- W2948402667 hasRelatedWork W2123506865 @default.
- W2948402667 hasRelatedWork W2130042602 @default.
- W2948402667 hasRelatedWork W2420223036 @default.
- W2948402667 hasRelatedWork W2469926537 @default.
- W2948402667 hasRelatedWork W3032786278 @default.
- W2948402667 hasVolume "68" @default.
- W2948402667 isParatext "false" @default.
- W2948402667 isRetracted "false" @default.
- W2948402667 magId "2948402667" @default.
- W2948402667 workType "article" @default.