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• W2948432613 abstract "A hallmark feature of schizophrenia is altered high frequency neural oscillations, including reduced auditory-evoked gamma oscillatory power, which is underpinned by parvalbumin (PV) interneuron dysfunction. Maternal immune activation (MIA) in rodents models an environmental risk factor for schizophrenia and recapitulates these PV interneuron changes. This study sought to link reduced PV expression in the MIA model with alterations to auditory-evoked gamma oscillations and transcript expression. We further aligned transcriptional findings from the animal model with human genome sequencing data. We show that MIA, induced by the viral mimetic, poly-I:C in C57Bl/6 mice, caused in adult offspring reduced auditory-evoked gamma and theta oscillatory power paralleled by reduced PV protein levels. We then showed the Arx gene, critical to healthy neurodevelopment of PV interneurons, is reduced in the forebrain of MIA exposed mice. Finally, in a whole-genome sequenced patient cohort, we identified a novel missense mutation of ARX in a patient with schizophrenia and in the Psychiatric Genomics Consortium 2 cohort, a nominal association of proximal ARX SNPs with the disorder. This suggests MIA, as a risk factor for schizophrenia, may be influencing Arx expression to induce the GABAergic dysfunction seen in schizophrenia and that the ARX gene may play a role in the prenatal origins of schizophrenia pathophysiology." @default.
• W2948432613 created "2019-06-14" @default.
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• W2948432613 date "2019-10-01" @default.
• W2948432613 modified "2023-10-15" @default.
• W2948432613 title "The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia" @default.
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• W2948432613 cites W1967445973 @default.
• W2948432613 cites W1968675910 @default.
• W2948432613 cites W1986097552 @default.
• W2948432613 cites W1987097017 @default.
• W2948432613 cites W2004710265 @default.
• W2948432613 cites W2005402594 @default.
• W2948432613 cites W2005839666 @default.
• W2948432613 cites W2015900850 @default.
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• W2948432613 cites W2068741295 @default.
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• W2948432613 cites W2086069938 @default.
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• W2948432613 cites W2164706220 @default.
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• W2948432613 doi "https://doi.org/10.1016/j.bbi.2019.06.009" @default.
• W2948432613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31175998" @default.
• W2948432613 hasPublicationYear "2019" @default.
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