FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948432891> ?p ?o ?g. }

• W2948432891 endingPage "2738" @default.
• W2948432891 startingPage "2738" @default.
• W2948432891 abstract "Clinical studies show a significant association of childhood adversities and FK506-binding protein 5 (FKBP5) polymorphisms on increasing the susceptibility for neuropsychiatric disorders. However, the mechanisms by which early life stress (ELS) influences FKBP5 actions have not been fully elucidated. We hypothesized that interactions between ELS and high FKBP5 induce phenotypic changes that correspond to underlying molecular changes in the brain. To test this, we exposed newborn mice overexpressing human FKBP5 in the forebrain, rTgFKBP5, to ELS using a maternal separation. Two months after ELS, we observed that ELS increased anxiety levels, specifically in mice overexpressing FKBP5, an effect that was more pronounced in females. Biochemically, Protein kinase B (AKT) phosphorylation was reduced in the dorsal hippocampus in rTgFKBP5 mice, which demonstrates that significant molecular changes occur as a result of ELS when FKBP5 levels are altered. Taken together, our results have a significant impact on our understanding mechanisms underlying the gene x environment interaction showing that anxiety and AKT signaling in the hippocampus were affected by the combination of ELS and FKBP5. An increased knowledge of the molecular mechanisms underlying these interactions may help determine if FKBP5 could be an effective target for the treatment of anxiety and other mood-related illnesses." @default.
• W2948432891 created "2019-06-14" @default.
• W2948432891 creator A5001543603 @default.
• W2948432891 creator A5016147283 @default.
• W2948432891 creator A5020361035 @default.
• W2948432891 creator A5033121696 @default.
• W2948432891 creator A5059605109 @default.
• W2948432891 creator A5071434472 @default.
• W2948432891 creator A5073645886 @default.
• W2948432891 creator A5089226509 @default.
• W2948432891 date "2019-06-04" @default.
• W2948432891 modified "2023-10-16" @default.
• W2948432891 title "Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus" @default.
• W2948432891 cites W140219456 @default.
• W2948432891 cites W1483825698 @default.
• W2948432891 cites W1511156001 @default.
• W2948432891 cites W1593021244 @default.
• W2948432891 cites W173386824 @default.
• W2948432891 cites W1758536687 @default.
• W2948432891 cites W1900401698 @default.
• W2948432891 cites W1913150253 @default.
• W2948432891 cites W1947456656 @default.
• W2948432891 cites W1970017566 @default.
• W2948432891 cites W1979620819 @default.
• W2948432891 cites W1984131837 @default.
• W2948432891 cites W1986875278 @default.
• W2948432891 cites W198999120 @default.
• W2948432891 cites W1991226287 @default.
• W2948432891 cites W1996667997 @default.
• W2948432891 cites W2000547748 @default.
• W2948432891 cites W2002074180 @default.
• W2948432891 cites W2009579074 @default.
• W2948432891 cites W2036194871 @default.
• W2948432891 cites W2044100668 @default.
• W2948432891 cites W2051005796 @default.
• W2948432891 cites W2051661459 @default.
• W2948432891 cites W2051719689 @default.
• W2948432891 cites W2059167203 @default.
• W2948432891 cites W2060812714 @default.
• W2948432891 cites W2060978874 @default.
• W2948432891 cites W2066563259 @default.
• W2948432891 cites W2066594068 @default.
• W2948432891 cites W2071880486 @default.
• W2948432891 cites W2084850612 @default.
• W2948432891 cites W2090645044 @default.
• W2948432891 cites W2091660013 @default.
• W2948432891 cites W2110496900 @default.
• W2948432891 cites W2115117609 @default.
• W2948432891 cites W2117055846 @default.
• W2948432891 cites W2126948325 @default.
• W2948432891 cites W2142373414 @default.
• W2948432891 cites W2150581383 @default.
• W2948432891 cites W2163659555 @default.
• W2948432891 cites W2171217262 @default.
• W2948432891 cites W2172105825 @default.
• W2948432891 cites W2306482506 @default.
• W2948432891 cites W2320359820 @default.
• W2948432891 cites W2485083839 @default.
• W2948432891 cites W2495321056 @default.
• W2948432891 cites W2586171856 @default.
• W2948432891 cites W2747881488 @default.
• W2948432891 cites W2912143836 @default.
• W2948432891 doi "https://doi.org/10.3390/ijms20112738" @default.
• W2948432891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600369" @default.
• W2948432891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31167373" @default.
• W2948432891 hasPublicationYear "2019" @default.
• W2948432891 type Work @default.
• W2948432891 sameAs 2948432891 @default.
• W2948432891 citedByCount "25" @default.
• W2948432891 countsByYear W29484328912020 @default.
• W2948432891 countsByYear W29484328912021 @default.
• W2948432891 countsByYear W29484328912022 @default.
• W2948432891 countsByYear W29484328912023 @default.
• W2948432891 crossrefType "journal-article" @default.
• W2948432891 hasAuthorship W2948432891A5001543603 @default.
• W2948432891 hasAuthorship W2948432891A5016147283 @default.
• W2948432891 hasAuthorship W2948432891A5020361035 @default.
• W2948432891 hasAuthorship W2948432891A5033121696 @default.
• W2948432891 hasAuthorship W2948432891A5059605109 @default.
• W2948432891 hasAuthorship W2948432891A5071434472 @default.
• W2948432891 hasAuthorship W2948432891A5073645886 @default.
• W2948432891 hasAuthorship W2948432891A5089226509 @default.
• W2948432891 hasBestOaLocation W29484328911 @default.
• W2948432891 hasConcept C118552586 @default.
• W2948432891 hasConcept C126322002 @default.
• W2948432891 hasConcept C15744967 @default.
• W2948432891 hasConcept C169760540 @default.
• W2948432891 hasConcept C2780841215 @default.
• W2948432891 hasConcept C2781161787 @default.
• W2948432891 hasConcept C558461103 @default.
• W2948432891 hasConcept C59493245 @default.
• W2948432891 hasConcept C71924100 @default.
• W2948432891 hasConcept C78150878 @default.
• W2948432891 hasConceptScore W2948432891C118552586 @default.
• W2948432891 hasConceptScore W2948432891C126322002 @default.
• W2948432891 hasConceptScore W2948432891C15744967 @default.
• W2948432891 hasConceptScore W2948432891C169760540 @default.
• W2948432891 hasConceptScore W2948432891C2780841215 @default.

• next