FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948443499> ?p ?o ?g. }

• W2948443499 endingPage "394" @default.
• W2948443499 startingPage "386" @default.
• W2948443499 abstract "The determination of endocannabinoids and endocannabinoid-like substances in biological human samples is a vibrant field of research with great significance due to postulated relevance of these substances in diseases such as Alzheimer's disease, multiple sclerosis, cancer and cardiovascular diseases. For a possible use as biomarker in early prediction or diagnosis of a disease as well as examination of a successful treatment, the valid determination of the analytes in common accessible human samples, such as plasma or serum, is of great importance. A method for the determination of arachidonoyl ethanolamide, oleoyl ethanolamide, palmitoyl ethanolamide, 1-arachidonoyl glycerol and 2-arachidonoyl glycerol in human K3EDTA plasma using liquid-liquid-extraction in combination with liquid chromatography-tandem-mass spectrometry has been developed and validated for the quantification of the aforementioned analytes. Particular emphasis was placed on the chromatographic separation of the isomers 1-arachidonoyl glycerol and 2-arachidonoyl glycerol, arachidonoyl ethanolamide and O-arachidonoyl ethanolamine (virodhamine) as well as oleoyl ethanolamide and vaccenic acid ethanolamide. During the validation process, increasing concentrations of 1-arachidonoyl glycerol and 2-arachidonoyl glycerol while storing plasma samples were observed. In-depth investigation of pre-analytical sample handling revealed rising concentrations for both analytes in plasma and for arachidonoyl ethanolamide, oleoyl ethanolamide and palmitoyl ethanolamide in whole blood, dependent on the period and temperature of storage. Prevention of the increase in concentration was not possible, raising the question whether human K3EDTA plasma is suitable for the determination of endocannabinoids and endocannabinoid-like substances. Especially the common practice to calculate the concentration of 2-arachidonoyl glycerol as sum of 1-arachidonoyl glycerol and 2-arachidonoyl glycerol is highly questionable because the concentrations of both analytes increase unequally while storing the plasma samples in the fridge." @default.
• W2948443499 created "2019-06-14" @default.
• W2948443499 creator A5002588358 @default.
• W2948443499 creator A5030072993 @default.
• W2948443499 creator A5038305604 @default.
• W2948443499 creator A5049276697 @default.
• W2948443499 creator A5078612562 @default.
• W2948443499 creator A5082692862 @default.
• W2948443499 creator A5085668312 @default.
• W2948443499 date "2019-11-01" @default.
• W2948443499 modified "2023-10-16" @default.
• W2948443499 title "Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma – LC-MS/MS method validation and pre-analytical characteristics" @default.
• W2948443499 cites W1964451576 @default.
• W2948443499 cites W1975994545 @default.
• W2948443499 cites W1991203527 @default.
• W2948443499 cites W2009775671 @default.
• W2948443499 cites W2010955280 @default.
• W2948443499 cites W2035522180 @default.
• W2948443499 cites W2044168079 @default.
• W2948443499 cites W2060052398 @default.
• W2948443499 cites W2068185361 @default.
• W2948443499 cites W2098981899 @default.
• W2948443499 cites W2106805933 @default.
• W2948443499 cites W2136399145 @default.
• W2948443499 cites W2155111805 @default.
• W2948443499 cites W2295932321 @default.
• W2948443499 cites W2395639552 @default.
• W2948443499 cites W2471377908 @default.
• W2948443499 cites W2602678884 @default.
• W2948443499 cites W2622087665 @default.
• W2948443499 cites W2725622653 @default.
• W2948443499 cites W2765408236 @default.
• W2948443499 cites W2800218694 @default.
• W2948443499 cites W2804915384 @default.
• W2948443499 cites W2805812631 @default.
• W2948443499 doi "https://doi.org/10.1016/j.talanta.2019.06.004" @default.
• W2948443499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31357310" @default.
• W2948443499 hasPublicationYear "2019" @default.
• W2948443499 type Work @default.
• W2948443499 sameAs 2948443499 @default.
• W2948443499 citedByCount "32" @default.
• W2948443499 countsByYear W29484434992020 @default.
• W2948443499 countsByYear W29484434992021 @default.
• W2948443499 countsByYear W29484434992022 @default.
• W2948443499 countsByYear W29484434992023 @default.
• W2948443499 crossrefType "journal-article" @default.
• W2948443499 hasAuthorship W2948443499A5002588358 @default.
• W2948443499 hasAuthorship W2948443499A5030072993 @default.
• W2948443499 hasAuthorship W2948443499A5038305604 @default.
• W2948443499 hasAuthorship W2948443499A5049276697 @default.
• W2948443499 hasAuthorship W2948443499A5078612562 @default.
• W2948443499 hasAuthorship W2948443499A5082692862 @default.
• W2948443499 hasAuthorship W2948443499A5085668312 @default.
• W2948443499 hasConcept C10390740 @default.
• W2948443499 hasConcept C148001335 @default.
• W2948443499 hasConcept C162356407 @default.
• W2948443499 hasConcept C170493617 @default.
• W2948443499 hasConcept C185592680 @default.
• W2948443499 hasConcept C2778938600 @default.
• W2948443499 hasConcept C2779783865 @default.
• W2948443499 hasConcept C3020134792 @default.
• W2948443499 hasConcept C31827203 @default.
• W2948443499 hasConcept C43617362 @default.
• W2948443499 hasConcept C46721173 @default.
• W2948443499 hasConcept C55493867 @default.
• W2948443499 hasConcept C64489805 @default.
• W2948443499 hasConceptScore W2948443499C10390740 @default.
• W2948443499 hasConceptScore W2948443499C148001335 @default.
• W2948443499 hasConceptScore W2948443499C162356407 @default.
• W2948443499 hasConceptScore W2948443499C170493617 @default.
• W2948443499 hasConceptScore W2948443499C185592680 @default.
• W2948443499 hasConceptScore W2948443499C2778938600 @default.
• W2948443499 hasConceptScore W2948443499C2779783865 @default.
• W2948443499 hasConceptScore W2948443499C3020134792 @default.
• W2948443499 hasConceptScore W2948443499C31827203 @default.
• W2948443499 hasConceptScore W2948443499C43617362 @default.
• W2948443499 hasConceptScore W2948443499C46721173 @default.
• W2948443499 hasConceptScore W2948443499C55493867 @default.
• W2948443499 hasConceptScore W2948443499C64489805 @default.
• W2948443499 hasFunder F4320320879 @default.
• W2948443499 hasLocation W29484434991 @default.
• W2948443499 hasLocation W29484434992 @default.
• W2948443499 hasOpenAccess W2948443499 @default.
• W2948443499 hasPrimaryLocation W29484434991 @default.
• W2948443499 hasRelatedWork W1976912150 @default.
• W2948443499 hasRelatedWork W1985186853 @default.
• W2948443499 hasRelatedWork W1995988713 @default.
• W2948443499 hasRelatedWork W1999163890 @default.
• W2948443499 hasRelatedWork W2003328801 @default.
• W2948443499 hasRelatedWork W2040912236 @default.
• W2948443499 hasRelatedWork W2041071791 @default.
• W2948443499 hasRelatedWork W2046598237 @default.
• W2948443499 hasRelatedWork W2049240931 @default.
• W2948443499 hasRelatedWork W2787820172 @default.
• W2948443499 hasVolume "204" @default.
• W2948443499 isParatext "false" @default.
• W2948443499 isRetracted "false" @default.
• W2948443499 magId "2948443499" @default.

• next