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- W2948447057 abstract "It has been shown that subjects with normal glucose tolerance (NGT) but elevated 1-hour glucose level ≧155 mg/dl during a 75g oral glucose tolerance test (75g OGTT) is an independent risk factor for type 2 diabetes. In Caucasian, subjects with elevated 1-h glucose were characterized by adiposity with lower insulin sensitivity and impaired beta-cell function. While type 2 diabetes in Asians is frequently affected in non-obese (BMI<25 kg/m2) subjects, the characteristics of non-obese Asians with elevated 1-h glucose are totally unknown. Here, we studied 59 non-obese Japanese men with NGT. Based on the level of 1-hour glucose level during 75g OGTT, we divided the subjects into Low-1 hour group (< 155mg/dl) and High-1 hour group (≧155mg/dl). We measured ectopic fat in muscle and liver and subcutaneous and viscera fat areas by 1H-MRS and MRI, respectively. We also measured tissue specific insulin sensitivity by 2 step hyperinsulinemic-euglycemic clamp. Insulinogenic index (0.66±0.30 vs. 1.41±1.21ΔInsulin0-30 min/ΔGlucose 0-30min, p=0.02) was significantly lower and area under the curve of glucose and insulin during 75g OGTT were significantly higher in High-1 hour group than Low-1 hour group (Figure). However, other parameters including insulin sensitivity and ectopic fat in muscle and liver, subcutaneous and viscera fat areas were comparable between the groups. These data suggest that non-obese Japanese men with High-1 hour glucose are characterized by impaired early-phase insulin secretion and subsequent hyperinsulinemia. Insulin resistance and abnormal fat distribution are not evident in this population." @default.
- W2948447057 created "2019-06-14" @default.
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- W2948447057 date "2019-06-01" @default.
- W2948447057 modified "2023-10-16" @default.
- W2948447057 title "1666-P: Metabolic Characteristic of Elevated One-Hour Plasma Glucose Levels during a 75g Oral Glucose Tolerance Test in the Nonobese Japanese Men" @default.
- W2948447057 doi "https://doi.org/10.2337/db19-1666-p" @default.
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