FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948468300> ?p ?o ?g. }

• W2948468300 endingPage "1445" @default.
• W2948468300 startingPage "1436" @default.
• W2948468300 abstract "OBJECTIVE Oxidative stress plays an important role in the pathophysiology of type 2 diabetes mellitus (T2DM). However, associations of biomarkers of oxidative stress with diabetes complications have not yet been addressed in large cohort studies. RESEARCH DESIGN AND METHODS Derivatives of reactive oxygen metabolites (d-ROMs) levels, a proxy for the reactive oxygen species burden, and total thiol levels (TTLs), a proxy for the reductive capacity, were measured in 2,125 patients with T2DM from two German cohort studies of almost equal size at baseline and 3–4 years later. Multivariable adjusted Cox proportional hazards models with time-dependent modeled d-ROMs levels and TTLs were used to assess the associations with incident major cardiovascular events (MCE), cancer incidence, and all-cause mortality. RESULTS In total, 205, 179, and 394 MCE, cancer, and all-cause mortality cases were observed during 6–7 years of follow-up, respectively. Both oxidative stress biomarkers and the d-ROMs-to-TTL ratio were statistically significantly associated with all-cause mortality in both cohorts, and the pooled hazard ratios (HRs) and 95% CIs for top versus bottom tertiles were 2.10 (95% CI 1.43, 3.09) for d-ROMs levels, 0.59 (0.40, 0.87) for TTLs, and 2.50 (1.86, 3.36) for d-ROMs-to-TTL ratio. The d-ROMs-to-TTL ratio was also statistically significantly associated with incident MCE for top versus bottom tertile (1.65 [1.07, 2.54]), but this association did not persist after additional adjustment for chronic diseases. No associations with cancer were detected. CONCLUSIONS The observed strong associations of both biomarkers with mortality suggest an important contribution of an imbalanced redox system to the premature mortality of patients with diabetes." @default.
• W2948468300 created "2019-06-14" @default.
• W2948468300 creator A5008576347 @default.
• W2948468300 creator A5021277858 @default.
• W2948468300 creator A5022779479 @default.
• W2948468300 creator A5028086873 @default.
• W2948468300 creator A5046905183 @default.
• W2948468300 creator A5055958896 @default.
• W2948468300 creator A5058394398 @default.
• W2948468300 creator A5077206620 @default.
• W2948468300 date "2019-06-04" @default.
• W2948468300 modified "2023-10-15" @default.
• W2948468300 title "Association of Serum Markers of Oxidative Stress With Incident Major Cardiovascular Events, Cancer Incidence, and All-Cause Mortality in Type 2 Diabetes Patients: Pooled Results From Two Cohort Studies" @default.
• W2948468300 cites W1163687489 @default.
• W2948468300 cites W1963489926 @default.
• W2948468300 cites W1968414870 @default.
• W2948468300 cites W2016716990 @default.
• W2948468300 cites W2017266270 @default.
• W2948468300 cites W2025939483 @default.
• W2948468300 cites W2033455837 @default.
• W2948468300 cites W2042127233 @default.
• W2948468300 cites W2045239299 @default.
• W2948468300 cites W2046708031 @default.
• W2948468300 cites W2046905205 @default.
• W2948468300 cites W2056639121 @default.
• W2948468300 cites W2092769218 @default.
• W2948468300 cites W2094142721 @default.
• W2948468300 cites W2103802232 @default.
• W2948468300 cites W2104195235 @default.
• W2948468300 cites W2105731956 @default.
• W2948468300 cites W2125209003 @default.
• W2948468300 cites W2144300287 @default.
• W2948468300 cites W2155888820 @default.
• W2948468300 cites W2157021841 @default.
• W2948468300 cites W2158106881 @default.
• W2948468300 cites W2170271198 @default.
• W2948468300 cites W2170591272 @default.
• W2948468300 cites W2197281791 @default.
• W2948468300 cites W2412299019 @default.
• W2948468300 cites W2488612907 @default.
• W2948468300 cites W2518059371 @default.
• W2948468300 cites W2626441385 @default.
• W2948468300 cites W2765283031 @default.
• W2948468300 cites W2810226429 @default.
• W2948468300 cites W2890739906 @default.
• W2948468300 cites W2899521318 @default.
• W2948468300 cites W2915142383 @default.
• W2948468300 doi "https://doi.org/10.2337/dc19-0292" @default.
• W2948468300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31167893" @default.
• W2948468300 hasPublicationYear "2019" @default.
• W2948468300 type Work @default.
• W2948468300 sameAs 2948468300 @default.
• W2948468300 citedByCount "22" @default.
• W2948468300 countsByYear W29484683002020 @default.
• W2948468300 countsByYear W29484683002021 @default.
• W2948468300 countsByYear W29484683002022 @default.
• W2948468300 countsByYear W29484683002023 @default.
• W2948468300 crossrefType "journal-article" @default.
• W2948468300 hasAuthorship W2948468300A5008576347 @default.
• W2948468300 hasAuthorship W2948468300A5021277858 @default.
• W2948468300 hasAuthorship W2948468300A5022779479 @default.
• W2948468300 hasAuthorship W2948468300A5028086873 @default.
• W2948468300 hasAuthorship W2948468300A5046905183 @default.
• W2948468300 hasAuthorship W2948468300A5055958896 @default.
• W2948468300 hasAuthorship W2948468300A5058394398 @default.
• W2948468300 hasAuthorship W2948468300A5077206620 @default.
• W2948468300 hasBestOaLocation W29484683001 @default.
• W2948468300 hasConcept C120665830 @default.
• W2948468300 hasConcept C121332964 @default.
• W2948468300 hasConcept C126322002 @default.
• W2948468300 hasConcept C134018914 @default.
• W2948468300 hasConcept C143998085 @default.
• W2948468300 hasConcept C201903717 @default.
• W2948468300 hasConcept C207103383 @default.
• W2948468300 hasConcept C2776151105 @default.
• W2948468300 hasConcept C2777180221 @default.
• W2948468300 hasConcept C44249647 @default.
• W2948468300 hasConcept C50382708 @default.
• W2948468300 hasConcept C555293320 @default.
• W2948468300 hasConcept C61511704 @default.
• W2948468300 hasConcept C71924100 @default.
• W2948468300 hasConcept C72563966 @default.
• W2948468300 hasConceptScore W2948468300C120665830 @default.
• W2948468300 hasConceptScore W2948468300C121332964 @default.
• W2948468300 hasConceptScore W2948468300C126322002 @default.
• W2948468300 hasConceptScore W2948468300C134018914 @default.
• W2948468300 hasConceptScore W2948468300C143998085 @default.
• W2948468300 hasConceptScore W2948468300C201903717 @default.
• W2948468300 hasConceptScore W2948468300C207103383 @default.
• W2948468300 hasConceptScore W2948468300C2776151105 @default.
• W2948468300 hasConceptScore W2948468300C2777180221 @default.
• W2948468300 hasConceptScore W2948468300C44249647 @default.
• W2948468300 hasConceptScore W2948468300C50382708 @default.
• W2948468300 hasConceptScore W2948468300C555293320 @default.
• W2948468300 hasConceptScore W2948468300C61511704 @default.
• W2948468300 hasConceptScore W2948468300C71924100 @default.
• W2948468300 hasConceptScore W2948468300C72563966 @default.
• W2948468300 hasFunder F4320320879 @default.

• next