FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948476004> ?p ?o ?g. }

• W2948476004 abstract "Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with cerebro-cerebellar damage in very preterm infants, leading to neurodevelopmental impairment. Penetration, from the intraventricular space, of extravasated red blood cells and extracellular hemoglobin (Hb), to the periventricular parenchyma and the cerebellum has been shown to be causal in the development of brain injury following GM-IVH. Furthermore, the damage has been described to be associated with the cytotoxic nature of extracellular Hb-metabolites. To date, there is no therapy available to prevent infants from developing either hydrocephalus or serious neurological disability. Mechanisms previously described to cause brain damage following GM-IVH, i.e., oxidative stress and Hb-metabolite toxicity, suggest that the free radical and heme scavenger α1-microglobulin (A1M) may constitute a potential neuroprotective intervention. Using a preterm rabbit pup model of IVH, where IVH was induced shortly after birth in pups delivered by cesarean section at E29 (3 days prior to term), we investigated the brain distribution of recombinant A1M (rA1M) following intracerebroventricular (i.c.v.) administration at 24 h post-IVH induction. Further, short-term functional protection of i.c.v.-administered human A1M (hA1M) following IVH in the preterm rabbit pup model was evaluated. Following i.c.v. administration, rA1M was distributed in periventricular white matter regions, throughout the fore- and midbrain and extending to the cerebellum. The regional distribution of rA1M was accompanied by a high co-existence of positive staining for extracellular Hb. Administration of i.c.v.-injected hA1M was associated with decreased structural tissue and mitochondrial damage and with reduced mRNA expression for proinflammatory and inflammatory signaling-related genes induced by IVH in periventricular brain tissue. The results of this study indicate that rA1M/hA1M is a potential candidate for neuroprotective treatment following preterm IVH." @default.
• W2948476004 created "2019-06-14" @default.
• W2948476004 creator A5003951650 @default.
• W2948476004 creator A5019279142 @default.
• W2948476004 creator A5031997958 @default.
• W2948476004 creator A5038712369 @default.
• W2948476004 creator A5040245316 @default.
• W2948476004 creator A5041902578 @default.
• W2948476004 creator A5049802907 @default.
• W2948476004 creator A5053838272 @default.
• W2948476004 creator A5054738281 @default.
• W2948476004 creator A5068316492 @default.
• W2948476004 creator A5073841069 @default.
• W2948476004 creator A5081295600 @default.
• W2948476004 creator A5090791150 @default.
• W2948476004 date "2019-06-07" @default.
• W2948476004 modified "2023-10-17" @default.
• W2948476004 title "The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage" @default.
• W2948476004 cites W1509804778 @default.
• W2948476004 cites W1547740703 @default.
• W2948476004 cites W1857797615 @default.
• W2948476004 cites W1962292479 @default.
• W2948476004 cites W1964780320 @default.
• W2948476004 cites W1968509137 @default.
• W2948476004 cites W1974659683 @default.
• W2948476004 cites W1980493860 @default.
• W2948476004 cites W1994857646 @default.
• W2948476004 cites W1996096944 @default.
• W2948476004 cites W2000361391 @default.
• W2948476004 cites W2000762378 @default.
• W2948476004 cites W2001546302 @default.
• W2948476004 cites W2006754144 @default.
• W2948476004 cites W2007644749 @default.
• W2948476004 cites W2009188523 @default.
• W2948476004 cites W2011737516 @default.
• W2948476004 cites W2014509822 @default.
• W2948476004 cites W2018419826 @default.
• W2948476004 cites W2021536767 @default.
• W2948476004 cites W2026733551 @default.
• W2948476004 cites W2026891878 @default.
• W2948476004 cites W2027665359 @default.
• W2948476004 cites W2029010155 @default.
• W2948476004 cites W2030218561 @default.
• W2948476004 cites W2039868172 @default.
• W2948476004 cites W2043151182 @default.
• W2948476004 cites W2046224474 @default.
• W2948476004 cites W2052714603 @default.
• W2948476004 cites W2054271640 @default.
• W2948476004 cites W2057576221 @default.
• W2948476004 cites W2059723632 @default.
• W2948476004 cites W2068805302 @default.
• W2948476004 cites W2069945130 @default.
• W2948476004 cites W2079636765 @default.
• W2948476004 cites W2087145590 @default.
• W2948476004 cites W2087293823 @default.
• W2948476004 cites W2092222846 @default.
• W2948476004 cites W2094365748 @default.
• W2948476004 cites W2095477436 @default.
• W2948476004 cites W2099607288 @default.
• W2948476004 cites W2102806222 @default.
• W2948476004 cites W2110572579 @default.
• W2948476004 cites W2112140599 @default.
• W2948476004 cites W2112836819 @default.
• W2948476004 cites W2115781221 @default.
• W2948476004 cites W2118133289 @default.
• W2948476004 cites W2122952930 @default.
• W2948476004 cites W2123064430 @default.
• W2948476004 cites W2134330663 @default.
• W2948476004 cites W2135776201 @default.
• W2948476004 cites W2140099191 @default.
• W2948476004 cites W2142230241 @default.
• W2948476004 cites W2153732322 @default.
• W2948476004 cites W2156480888 @default.
• W2948476004 cites W2159781224 @default.
• W2948476004 cites W2170398304 @default.
• W2948476004 cites W2180442504 @default.
• W2948476004 cites W2228866506 @default.
• W2948476004 cites W2239467861 @default.
• W2948476004 cites W2265368806 @default.
• W2948476004 cites W2341358513 @default.
• W2948476004 cites W2484006275 @default.
• W2948476004 cites W2563495825 @default.
• W2948476004 cites W2624649854 @default.
• W2948476004 cites W2751592592 @default.
• W2948476004 cites W2766385998 @default.
• W2948476004 cites W2793151925 @default.
• W2948476004 cites W2802148572 @default.
• W2948476004 cites W2809760991 @default.
• W2948476004 cites W4230455677 @default.
• W2948476004 doi "https://doi.org/10.1186/s12974-019-1486-4" @default.
• W2948476004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6554963" @default.
• W2948476004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31174551" @default.
• W2948476004 hasPublicationYear "2019" @default.
• W2948476004 type Work @default.
• W2948476004 sameAs 2948476004 @default.
• W2948476004 citedByCount "22" @default.
• W2948476004 countsByYear W29484760042019 @default.
• W2948476004 countsByYear W29484760042020 @default.
• W2948476004 countsByYear W29484760042021 @default.
• W2948476004 countsByYear W29484760042022 @default.

• next