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• W2948487375 endingPage "e1006994" @default.
• W2948487375 startingPage "e1006994" @default.
• W2948487375 abstract "The computational reconstruction of genome sequences from shotgun sequencing data has been greatly simplified by the advent of sequencing technologies that generate long reads. In the case of relatively small genomes (e.g., bacterial or viral), complete genome sequences can frequently be reconstructed computationally without the need for further experiments. However, large and complex genomes, such as those of most animals and plants, continue to pose significant challenges. In such genomes, assembly software produces incomplete and fragmented reconstructions that require additional experimentally derived information and manual intervention in order to reconstruct individual chromosome arms. Recent technologies originally designed to capture chromatin structure have been shown to effectively complement sequencing data, leading to much more contiguous reconstructions of genomes than previously possible. Here, we survey these technologies and the algorithms used to assemble and analyze large eukaryotic genomes, placed within the historical context of genome scaffolding technologies that have been in existence since the dawn of the genomic era." @default.
• W2948487375 created "2019-06-14" @default.
• W2948487375 creator A5053208854 @default.
• W2948487375 creator A5064979917 @default.
• W2948487375 date "2019-06-05" @default.
• W2948487375 modified "2023-10-12" @default.
• W2948487375 title "Modern technologies and algorithms for scaffolding assembled genomes" @default.
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