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- W2948494241 abstract "Strong inter-individual variation in clinical response to immune checkpoint inhibitors (ICB) remains a major challenge, but the molecular pathways that modulate ICB efficacy remain ill defined. Here we demonstrate that anti-CTLA-4 immunotherapy relies on tumor cell-intrinsic activation of the cytosolic RNA receptor RIG-I. Following anti-CTLA-4 treatment, tumor-intrinsic RIG-I signaling critically impacts on cross-presentation of tumor-associated antigen by CD103+ dendritic cells, the expansion of tumor antigen-specific CD8+ T cells and the accumulation these cells within tumor tissue. In addition, therapeutic targeting of RIG-I with 5’-phosphorylated-RNA in both tumor and non-malignant host cells potently augments the efficacy of CTLA-4 checkpoint blockade." @default.
- W2948494241 created "2019-06-14" @default.
- W2948494241 creator A5065381669 @default.
- W2948494241 date "2018-01-01" @default.
- W2948494241 modified "2023-09-27" @default.
- W2948494241 title "Tumor immunosurveiliance: Innate immune activation as a mechanistic prerequisite for efficient immune checkpoint blockade in cancer immunotherapy" @default.
- W2948494241 hasPublicationYear "2018" @default.
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