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- W2948548824 abstract "Abstract Predictive models can enhance the salience of unanticipated input, and the neocortical laminar architecture is believed to be central to this computation. Here, we examined the role of a key potential node in model formation, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse somatosensory cortex. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory-responsive, without affecting overall firing rates in L6 or L2/3. This stimulation suppressed L2/3 deviance encoding, but maintained other stimulus encoding. The stimulation also selectively suppressed behavioral sensitivity to deviant stimuli without impacting baseline performance. In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function. These findings indicate that, despite their sparse activity, specific ensembles of stimulus-driven L6 neurons are required to form neocortical predictions, and for their behavioral benefit." @default.
- W2948548824 created "2019-06-14" @default.
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- W2948548824 date "2019-06-03" @default.
- W2948548824 modified "2023-10-18" @default.
- W2948548824 title "Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants" @default.
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- W2948548824 doi "https://doi.org/10.1101/657114" @default.
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