Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948551806> ?p ?o ?g. }
- W2948551806 endingPage "1269" @default.
- W2948551806 startingPage "1255" @default.
- W2948551806 abstract "Abstract A genomics approach is an effective way to understand the possible mechanisms underlying the onset and progression of disease. However, very limited results have been published regarding whole-genome expression analysis of human idiopathic membranous nephropathy (iMN) using renal tissue. In the present study, gene expression profiling using renal cortex tissue from iMN patients and healthy controls was conducted; differentially expressed genes (DEGs) were filtered out, and 167 up- and 291 down-regulated genes were identified as overlapping DEGs (ODEGs). Moreover, enrichment analysis and protein–protein network construction were performed, revealing enrichment of genes mainly in cholesterol metabolism and arachidonic acid metabolism, among others, with 38 hub genes obtained. Furthermore, we found several associations between circulating lipid concentrations and hub gene signal intensities in the renal cortex. Our findings indicate that lipid metabolism, including cholesterol metabolism and arachidonic acid metabolism, may participate in iMN pathogenesis through key genes, including apolipoprotein A1 (APOA1), apolipoprotein B (APOB), apolipoprotein C3 (APOC3), cholesteryl ester transfer protein (CETP), and phospholipase A2 group XIIB (PLA2G12B)." @default.
- W2948551806 created "2019-06-14" @default.
- W2948551806 creator A5017839135 @default.
- W2948551806 creator A5022589910 @default.
- W2948551806 creator A5025431572 @default.
- W2948551806 creator A5025551264 @default.
- W2948551806 creator A5064689184 @default.
- W2948551806 creator A5085801296 @default.
- W2948551806 date "2019-06-01" @default.
- W2948551806 modified "2023-10-02" @default.
- W2948551806 title "Lipid metabolism participates in human membranous nephropathy identified by whole-genome gene expression profiling" @default.
- W2948551806 cites W1975315532 @default.
- W2948551806 cites W1986167294 @default.
- W2948551806 cites W2008486735 @default.
- W2948551806 cites W2019602081 @default.
- W2948551806 cites W2029198423 @default.
- W2948551806 cites W2041097543 @default.
- W2948551806 cites W2047072740 @default.
- W2948551806 cites W2057824539 @default.
- W2948551806 cites W2058659021 @default.
- W2948551806 cites W2075040156 @default.
- W2948551806 cites W2076646551 @default.
- W2948551806 cites W2083760961 @default.
- W2948551806 cites W2089123887 @default.
- W2948551806 cites W2093216680 @default.
- W2948551806 cites W2106648568 @default.
- W2948551806 cites W2131516683 @default.
- W2948551806 cites W2138543166 @default.
- W2948551806 cites W2140753937 @default.
- W2948551806 cites W2146310869 @default.
- W2948551806 cites W2154852379 @default.
- W2948551806 cites W2166822765 @default.
- W2948551806 cites W2267551216 @default.
- W2948551806 cites W2295047040 @default.
- W2948551806 cites W2337407464 @default.
- W2948551806 cites W2409610111 @default.
- W2948551806 cites W2559588208 @default.
- W2948551806 cites W2604808360 @default.
- W2948551806 cites W2617482626 @default.
- W2948551806 cites W2625438639 @default.
- W2948551806 cites W2765271365 @default.
- W2948551806 cites W2802079625 @default.
- W2948551806 cites W2885366532 @default.
- W2948551806 cites W2895605837 @default.
- W2948551806 cites W2930353056 @default.
- W2948551806 cites W53296430 @default.
- W2948551806 doi "https://doi.org/10.1042/cs20181110" @default.
- W2948551806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31160422" @default.
- W2948551806 hasPublicationYear "2019" @default.
- W2948551806 type Work @default.
- W2948551806 sameAs 2948551806 @default.
- W2948551806 citedByCount "9" @default.
- W2948551806 countsByYear W29485518062021 @default.
- W2948551806 countsByYear W29485518062022 @default.
- W2948551806 countsByYear W29485518062023 @default.
- W2948551806 crossrefType "journal-article" @default.
- W2948551806 hasAuthorship W2948551806A5017839135 @default.
- W2948551806 hasAuthorship W2948551806A5022589910 @default.
- W2948551806 hasAuthorship W2948551806A5025431572 @default.
- W2948551806 hasAuthorship W2948551806A5025551264 @default.
- W2948551806 hasAuthorship W2948551806A5064689184 @default.
- W2948551806 hasAuthorship W2948551806A5085801296 @default.
- W2948551806 hasConcept C104317684 @default.
- W2948551806 hasConcept C126322002 @default.
- W2948551806 hasConcept C134018914 @default.
- W2948551806 hasConcept C181199279 @default.
- W2948551806 hasConcept C2776991927 @default.
- W2948551806 hasConcept C2778078955 @default.
- W2948551806 hasConcept C2778163477 @default.
- W2948551806 hasConcept C2779134260 @default.
- W2948551806 hasConcept C4733338 @default.
- W2948551806 hasConcept C55493867 @default.
- W2948551806 hasConcept C57089818 @default.
- W2948551806 hasConcept C62746215 @default.
- W2948551806 hasConcept C71924100 @default.
- W2948551806 hasConcept C86803240 @default.
- W2948551806 hasConceptScore W2948551806C104317684 @default.
- W2948551806 hasConceptScore W2948551806C126322002 @default.
- W2948551806 hasConceptScore W2948551806C134018914 @default.
- W2948551806 hasConceptScore W2948551806C181199279 @default.
- W2948551806 hasConceptScore W2948551806C2776991927 @default.
- W2948551806 hasConceptScore W2948551806C2778078955 @default.
- W2948551806 hasConceptScore W2948551806C2778163477 @default.
- W2948551806 hasConceptScore W2948551806C2779134260 @default.
- W2948551806 hasConceptScore W2948551806C4733338 @default.
- W2948551806 hasConceptScore W2948551806C55493867 @default.
- W2948551806 hasConceptScore W2948551806C57089818 @default.
- W2948551806 hasConceptScore W2948551806C62746215 @default.
- W2948551806 hasConceptScore W2948551806C71924100 @default.
- W2948551806 hasConceptScore W2948551806C86803240 @default.
- W2948551806 hasIssue "11" @default.
- W2948551806 hasLocation W29485518061 @default.
- W2948551806 hasLocation W29485518062 @default.
- W2948551806 hasOpenAccess W2948551806 @default.
- W2948551806 hasPrimaryLocation W29485518061 @default.
- W2948551806 hasRelatedWork W1960389768 @default.
- W2948551806 hasRelatedWork W1990495554 @default.
- W2948551806 hasRelatedWork W1995560415 @default.