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• W2948561820 abstract "Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 and 0.70 mg/kg nicotine. Both mouse strains showed significantly altered respiratory and locomotion phenotypes relative to saline-injected controls when administered the higher dose, but only C57BL/6J responded to the lower nicotine dose. Respiratory and locomotion phenotypes rarely differed significantly by sex. To investigate whether the strain-specific differences in nicotine sensitivity were related to differences in clearance, we followed up by measuring nicotine clearance in C3H/HeJ and C57BL/6J mice (0.35 mg/kg subcutaneous) and found sex differences in both strains, but no difference between strains." @default.
• W2948561820 created "2019-06-14" @default.
• W2948561820 creator A5004526431 @default.
• W2948561820 date "2019-06-21" @default.
• W2948561820 modified "2023-09-24" @default.
• W2948561820 title "Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism" @default.
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• W2948561820 doi "https://doi.org/10.1080/15376516.2019.1628141" @default.
• W2948561820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6660405" @default.
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