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- W2948565575 abstract "REALI pooled database, encompassing Gla-300 studies conducted in different European countries, is a platform to identify factors contributing to glycemic control in patients with uncontrolled T2D initiated on Gla-300. A stepwise multivariable regression analysis was performed on selected demographic and baseline characteristics associated with achieving HbA1c target <7.5% after 6 months of Gla-300 treatment from 8 studies (3 interventional and 5 observational). The criterion for consideration and inclusion in the model was p < 0.05. Among 2558 subjects included, 48.7% reached target HbA1C <7.5%, 56% were male and 37% were insulin naïve. Mean (SD) age was 64 (9.4) years and BMI was 32.2 (5.3) kg/m2. Mean (SD) baseline HbA1c was 8.5 (1) % and starting Gla-300 dose 0.29 (0.18) U/kg/day. The analyses identified baseline HbA1c as the major predictive factor associated with achievement of HbA1c target <7.5%, with a nonlinear relationship, and odds were higher in the lowest baseline HbA1c value (p<0.0001). Male gender (p=0.0014), being insulin naïve (p<0.0001), and lower Gla-300 starting dose (p=0.0015) were also identified as potential predictors for achieving HbA1c target <7.5%. These results can help clinicians to identify patients with T2D treated with Gla-300, who are likely to achieve target HbA1c <7.5%." @default.
- W2948565575 created "2019-06-14" @default.
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- W2948565575 date "2019-06-01" @default.
- W2948565575 modified "2023-09-24" @default.
- W2948565575 title "2328-PUB: Identification by Multivariable Analysis of Predictive Factors of HbA1c Target Achievement in People with T2D Initiating Treatment with Insulin Glargine 300 U/mL (Gla-300)—REALI Pooled Database" @default.
- W2948565575 doi "https://doi.org/10.2337/db19-2328-pub" @default.
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