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• W2948571135 endingPage "111403" @default.
• W2948571135 startingPage "111403" @default.
• W2948571135 abstract "In the present work, peptide-functionalized [email protected] nanoparticle (termed as [email protected]2@Cy5-pep)-based fluorescence resonance energy transfer (FRET) sensing platform has been fabricated for the detection of caspase-9 activity in vitro and in vivo. A Cy5 labeled peptide containing specific motif LEHD for caspase-9 cleavage was designed and conjugated with [email protected]2 through covalent attachment. The red upconversion luminescence (UCL) emission of [email protected]2 can be quenched by Cy5 while the green UCL emission of [email protected]2 remains undisturbed. After the cleavage of LEHD by caspase-9, the Cy5 departed from [email protected]2 surface, resulting in recovery of red UCL emission of [email protected]2. The [email protected]2@Cy5-pep has been successfully used to monitoring the changes of caspase-9 activity levels in apoptotic cancerous cells (MG-63 and SW480) by cisplatin-induction. Under same experimental conditions, it is found that the intracellular caspase-9 activity level of cisplatin-treated MG-63 cells is higher than that of cisplatin-treated SW480. This result is consistent with that of commercial caspase-9 activity kits. The UCL signal intensity ratio of red emission to green emission of UCNP (termed as R/G) is linearly dependent on the amount of MG-63 cells within the range of 5 × 103 to 1 × 106 cells (i.e., 0.5–100 U mL−1 caspase-9) with a limit of detection (LOD) of 675 cells (i.e., 0.068 U mL−1 caspase-9). Furthermore, the practicability of [email protected]2@Cy5-pep is demonstrated by detection of caspase-9 activities in tumor tissues in vivo, and satisfactory results are obtained." @default.
• W2948571135 created "2019-06-14" @default.
• W2948571135 creator A5007978503 @default.
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• W2948571135 date "2019-09-01" @default.
• W2948571135 modified "2023-10-02" @default.
• W2948571135 title "Peptide-functionalized upconversion nanoparticles-based FRET sensing platform for Caspase-9 activity detection in vitro and in vivo" @default.
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• W2948571135 doi "https://doi.org/10.1016/j.bios.2019.111403" @default.
• W2948571135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31176111" @default.
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