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- W2948572012 abstract "The systemic administration of lidocaine (often known by its approved British name, lignocaine) by intravenous or subcutaneous infusion is a practice that is growing in popularity. To date, studies investigating the effects of lidocaine on the perioperative course provide some evidence that intraoperative lidocaine may be a useful adjunct to general anaesthesia. They are however, as yet, uncompelling. Systemic lidocaine is administered principally for the purpose of improved perioperative analgesia. There are other outcomes, however, which potentially may be influenced by systemic lidocaine administration; namely the risk of postoperative infection, malignancy recurrence, and the incidence of chronic post-surgical pain (CPSP). The mechanisms by which systemic lidocaine can impair pain pathways, alter inflammation and immune competence, are enlightening and will be covered in this review. A summary of the evidence investigating the clinical outcomes will also feature. A number of questions still exist surrounding the practicalities of lidocaine's intravenous use and these will be explored in addition to the potential avenues of research which are required to determine whether a lidocaine infusion is simply an intervention that benefits the occasional patient, or whether it provides advantages too great to ignore." @default.
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- W2948572012 date "2017-01-01" @default.
- W2948572012 modified "2023-09-23" @default.
- W2948572012 title "Lidocaine infusions: The golden ticket in postoperative recovery?" @default.
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