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- W2948585465 abstract "Background The dynamic changes of serum circRNAs, which act as a sponge of microRNA, has a great potential in predicting colonic disease, especially in malignant diseases. However, whether the mechanism of circRNA in regulating colonic epithelial mucosa is still unknown. Here, we explore the sponging effects of hsa_circ_0053063 targeting miR-361-3p in colon epithelial cells. Methods According to the ceRNA analysis, the potential target miRNAs of hsa_circ_0053063 were collected. Dual-luciferase reporter gene assays were performed to confirm the circRNA sponge of miRNAs. Then the potential target gene of miR-361-3p was predicted. Dual-luciferase reporter gene assays and real-time PCR were performed to detect the regulation between ncRNAs and target gene in colon epithelial cells HCoEpiC and NCM460. Results According to the ceRNA analysis, we found that miR-361-3p might be a target of hsa_circ_0053063 (figure 1a). Dual-luciferase reporter gene assays demonstrated that hsa_circ_0053063 bound miR-361-3p directly (figure 1b). Then we predicted that ATG13 was a target gene of miR-361-3p. Dual-luciferase reporter gene assays demonstrated that miR-361-3p bound ATG13 directly. Real-time PCR revealed that miR-361-3p decreased expression of ATG13, however, hsa_circ_0053063 reversed the inhibition of expression of ATG13 by miR-361-3p. Conclusions Hsa_circ_0053063 released the inhibition of expression of ATG13 by miR-361-3p. hsa_circ_0053063 may act as a sponge of miR-361-3p targeting ATG13 in colon epithelial cell." @default.
- W2948585465 created "2019-06-14" @default.
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- W2948585465 date "2019-06-01" @default.
- W2948585465 modified "2023-09-25" @default.
- W2948585465 title "IDDF2019-ABS-0089 Hsa_circ_0053063 acts as a sponge of miR-361–3p in colon epithelial cells" @default.
- W2948585465 doi "https://doi.org/10.1136/gutjnl-2019-iddfabstracts.24" @default.
- W2948585465 hasPublicationYear "2019" @default.
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