FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948616110> ?p ?o ?g. }

• W2948616110 endingPage "111414" @default.
• W2948616110 startingPage "111414" @default.
• W2948616110 abstract "We herein report the first attempt to engineer a coaxial-sensing 3D amplifier able to achieve dynamic self-assembly in response to a mutated-ctDNA target. A bio-nanofiber is firstly manufactured via an ingenious double-channel electrostatic spinning and DNA rolling circle replication (RCR) technology, which offered an ideal scaffold for assembly of 3D amplifier activated by target recognition. The coaxial-controllable signal amplifier presented several advantages. (1) Given its “coaxial sensing effect”, the proposed bio-amplifier played the coaxial transduction for signal enrichment to vastly increase sensitivity, capable of discriminating a single-base mismatched sequence from the perfectly complementary one, using ctDNA-134A as a model analyte. (2) Due to “covalent bridges lock effect” in an identifying chip with locked nucleic acid beacons, this 3D amplifier expressed high specificity and biostability toward seven different mutated-ctDNAs. (3) Profiting from special configuration of bioactive nanofibers and DNA replication programming, this catalytic bio-amplifier possessed “signal enrichment effect”, which enhanced dynamic range toward ctDNA-134A detection and hybridized without any external indicators. This innovative bio-amplifier has a detection limit of 5.1 aM for ctDNA-134A with superior specificity, excellent sensitivity, and good performance. This pioneered method was further applied for broadly differentiate cells and evaluate changes in the expression levels of intracellular mutated-ctDNAs." @default.
• W2948616110 created "2019-06-14" @default.
• W2948616110 creator A5003681868 @default.
• W2948616110 creator A5005398821 @default.
• W2948616110 creator A5018066024 @default.
• W2948616110 creator A5019520897 @default.
• W2948616110 creator A5038380923 @default.
• W2948616110 creator A5065590805 @default.
• W2948616110 date "2019-09-01" @default.
• W2948616110 modified "2023-10-16" @default.
• W2948616110 title "Coaxial sensing bio-amplifier for ultrasensitive detections of circulating tumor DNAs" @default.
• W2948616110 cites W1461294855 @default.
• W2948616110 cites W1806975025 @default.
• W2948616110 cites W1967584331 @default.
• W2948616110 cites W1983466841 @default.
• W2948616110 cites W1994584281 @default.
• W2948616110 cites W1998427002 @default.
• W2948616110 cites W2003321071 @default.
• W2948616110 cites W2027679544 @default.
• W2948616110 cites W2043157211 @default.
• W2948616110 cites W2072765132 @default.
• W2948616110 cites W2078805336 @default.
• W2948616110 cites W2103931611 @default.
• W2948616110 cites W2113194941 @default.
• W2948616110 cites W2117692326 @default.
• W2948616110 cites W2133380348 @default.
• W2948616110 cites W2134142320 @default.
• W2948616110 cites W2149414866 @default.
• W2948616110 cites W2295568596 @default.
• W2948616110 cites W2329098684 @default.
• W2948616110 cites W2560389953 @default.
• W2948616110 cites W2563114532 @default.
• W2948616110 cites W2593435710 @default.
• W2948616110 cites W2595968259 @default.
• W2948616110 cites W2608738563 @default.
• W2948616110 cites W2616925143 @default.
• W2948616110 cites W2748647436 @default.
• W2948616110 cites W2760464869 @default.
• W2948616110 cites W2764195238 @default.
• W2948616110 cites W2793969139 @default.
• W2948616110 cites W2795146457 @default.
• W2948616110 cites W2808752358 @default.
• W2948616110 cites W2883718213 @default.
• W2948616110 cites W4234746319 @default.
• W2948616110 cites W4235642752 @default.
• W2948616110 cites W4376848401 @default.
• W2948616110 doi "https://doi.org/10.1016/j.bios.2019.111414" @default.
• W2948616110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31195204" @default.
• W2948616110 hasPublicationYear "2019" @default.
• W2948616110 type Work @default.
• W2948616110 sameAs 2948616110 @default.
• W2948616110 citedByCount "5" @default.
• W2948616110 countsByYear W29486161102020 @default.
• W2948616110 countsByYear W29486161102022 @default.
• W2948616110 countsByYear W29486161102023 @default.
• W2948616110 crossrefType "journal-article" @default.
• W2948616110 hasAuthorship W2948616110A5003681868 @default.
• W2948616110 hasAuthorship W2948616110A5005398821 @default.
• W2948616110 hasAuthorship W2948616110A5018066024 @default.
• W2948616110 hasAuthorship W2948616110A5019520897 @default.
• W2948616110 hasAuthorship W2948616110A5038380923 @default.
• W2948616110 hasAuthorship W2948616110A5065590805 @default.
• W2948616110 hasConcept C10390740 @default.
• W2948616110 hasConcept C171250308 @default.
• W2948616110 hasConcept C185592680 @default.
• W2948616110 hasConcept C192562407 @default.
• W2948616110 hasConcept C194257627 @default.
• W2948616110 hasConcept C199360897 @default.
• W2948616110 hasConcept C2779843651 @default.
• W2948616110 hasConcept C41008148 @default.
• W2948616110 hasConcept C43617362 @default.
• W2948616110 hasConcept C46362747 @default.
• W2948616110 hasConcept C49040817 @default.
• W2948616110 hasConcept C51221625 @default.
• W2948616110 hasConcept C552990157 @default.
• W2948616110 hasConcept C55493867 @default.
• W2948616110 hasConcept C73573662 @default.
• W2948616110 hasConcept C7452308 @default.
• W2948616110 hasConcept C76155785 @default.
• W2948616110 hasConceptScore W2948616110C10390740 @default.
• W2948616110 hasConceptScore W2948616110C171250308 @default.
• W2948616110 hasConceptScore W2948616110C185592680 @default.
• W2948616110 hasConceptScore W2948616110C192562407 @default.
• W2948616110 hasConceptScore W2948616110C194257627 @default.
• W2948616110 hasConceptScore W2948616110C199360897 @default.
• W2948616110 hasConceptScore W2948616110C2779843651 @default.
• W2948616110 hasConceptScore W2948616110C41008148 @default.
• W2948616110 hasConceptScore W2948616110C43617362 @default.
• W2948616110 hasConceptScore W2948616110C46362747 @default.
• W2948616110 hasConceptScore W2948616110C49040817 @default.
• W2948616110 hasConceptScore W2948616110C51221625 @default.
• W2948616110 hasConceptScore W2948616110C552990157 @default.
• W2948616110 hasConceptScore W2948616110C55493867 @default.
• W2948616110 hasConceptScore W2948616110C73573662 @default.
• W2948616110 hasConceptScore W2948616110C7452308 @default.
• W2948616110 hasConceptScore W2948616110C76155785 @default.
• W2948616110 hasFunder F4320321001 @default.
• W2948616110 hasFunder F4320324174 @default.

• next