Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948652499> ?p ?o ?g. }
- W2948652499 endingPage "2849" @default.
- W2948652499 startingPage "2841" @default.
- W2948652499 abstract "Abstract NAD(P)H quinone oxidoreductase‐1 (NQO1) is a homodimeric protein that acts as a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the NAD(P)H binding site and can both inhibit enzyme activity and modulate the interaction of NQO1 with other proteins. We show that the binding of dicoumarol and related compounds to NQO1 generates negative cooperativity between the monomers. This does not occur in the presence of the reducing cofactor, NAD(P)H, alone. Alteration of Gly150 (but not Gly149 or Gly174) abolished the dicoumarol‐induced negative cooperativity. Analysis of the dynamics of NQO1 with the Gaussian network model indicates a high degree of collective motion by monomers and domains within NQO1. Ligand binding is predicted to alter NQO1 dynamics both proximal to the ligand binding site and remotely, close to the second binding site. Thus, drug‐induced modulation of protein motion might contribute to the biological effects of putative inhibitors of NQO1." @default.
- W2948652499 created "2019-06-14" @default.
- W2948652499 creator A5007546946 @default.
- W2948652499 creator A5012690870 @default.
- W2948652499 creator A5015189393 @default.
- W2948652499 creator A5033987560 @default.
- W2948652499 creator A5039044122 @default.
- W2948652499 creator A5045152103 @default.
- W2948652499 creator A5046412404 @default.
- W2948652499 creator A5047090367 @default.
- W2948652499 creator A5052068472 @default.
- W2948652499 creator A5054557118 @default.
- W2948652499 creator A5065281989 @default.
- W2948652499 date "2019-09-20" @default.
- W2948652499 modified "2023-10-18" @default.
- W2948652499 title "Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)" @default.
- W2948652499 cites W1417333514 @default.
- W2948652499 cites W1503552721 @default.
- W2948652499 cites W1565248232 @default.
- W2948652499 cites W1569233292 @default.
- W2948652499 cites W1762836999 @default.
- W2948652499 cites W1963953060 @default.
- W2948652499 cites W1967544359 @default.
- W2948652499 cites W1972964958 @default.
- W2948652499 cites W1975317507 @default.
- W2948652499 cites W1977637450 @default.
- W2948652499 cites W1983032234 @default.
- W2948652499 cites W1990780198 @default.
- W2948652499 cites W1990927292 @default.
- W2948652499 cites W1991007595 @default.
- W2948652499 cites W1994957496 @default.
- W2948652499 cites W1997429227 @default.
- W2948652499 cites W2005474992 @default.
- W2948652499 cites W2018922462 @default.
- W2948652499 cites W2019260291 @default.
- W2948652499 cites W2024258033 @default.
- W2948652499 cites W2024568523 @default.
- W2948652499 cites W2024603645 @default.
- W2948652499 cites W2037816363 @default.
- W2948652499 cites W2040121494 @default.
- W2948652499 cites W2040402078 @default.
- W2948652499 cites W2042086711 @default.
- W2948652499 cites W2042567882 @default.
- W2948652499 cites W2053536319 @default.
- W2948652499 cites W2053743600 @default.
- W2948652499 cites W2055155126 @default.
- W2948652499 cites W2056650214 @default.
- W2948652499 cites W2059112746 @default.
- W2948652499 cites W2061015706 @default.
- W2948652499 cites W2069764626 @default.
- W2948652499 cites W2087542439 @default.
- W2948652499 cites W2087878478 @default.
- W2948652499 cites W2089869974 @default.
- W2948652499 cites W2093397766 @default.
- W2948652499 cites W2099952208 @default.
- W2948652499 cites W2101017457 @default.
- W2948652499 cites W2102427015 @default.
- W2948652499 cites W2108700551 @default.
- W2948652499 cites W2114876189 @default.
- W2948652499 cites W2116418823 @default.
- W2948652499 cites W2121545035 @default.
- W2948652499 cites W2132595034 @default.
- W2948652499 cites W2138620839 @default.
- W2948652499 cites W2148385534 @default.
- W2948652499 cites W2154339406 @default.
- W2948652499 cites W2159551001 @default.
- W2948652499 cites W2160975112 @default.
- W2948652499 cites W2163921018 @default.
- W2948652499 cites W2168798454 @default.
- W2948652499 cites W2218941725 @default.
- W2948652499 cites W2223938323 @default.
- W2948652499 cites W2313032913 @default.
- W2948652499 cites W2313910402 @default.
- W2948652499 cites W2398388055 @default.
- W2948652499 cites W2612243116 @default.
- W2948652499 cites W2709915882 @default.
- W2948652499 cites W2733048333 @default.
- W2948652499 cites W2743061231 @default.
- W2948652499 cites W2766503732 @default.
- W2948652499 cites W2902288754 @default.
- W2948652499 cites W2944313696 @default.
- W2948652499 cites W4232877717 @default.
- W2948652499 cites W4242267978 @default.
- W2948652499 cites W986771618 @default.
- W2948652499 doi "https://doi.org/10.1002/cbic.201900313" @default.
- W2948652499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31165578" @default.
- W2948652499 hasPublicationYear "2019" @default.
- W2948652499 type Work @default.
- W2948652499 sameAs 2948652499 @default.
- W2948652499 citedByCount "16" @default.
- W2948652499 countsByYear W29486524992019 @default.
- W2948652499 countsByYear W29486524992020 @default.
- W2948652499 countsByYear W29486524992021 @default.
- W2948652499 countsByYear W29486524992022 @default.
- W2948652499 countsByYear W29486524992023 @default.
- W2948652499 crossrefType "journal-article" @default.
- W2948652499 hasAuthorship W2948652499A5007546946 @default.
- W2948652499 hasAuthorship W2948652499A5012690870 @default.