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- W2948656340 endingPage "175883591985344" @default.
- W2948656340 startingPage "175883591985344" @default.
- W2948656340 abstract "Sex-determining region Y-related high-mobility-group box transcription factor 11 (SOX11) is an essential member of the SOX transcription factors and has been highlighted as an important regulator in embryogenesis. SOX11 studies have only recently shifted focus from its role in embryogenesis and development to its function in disease. In particular, the role of SOX11 in carcinogenesis has become of major interest in the field. SOX11 expression is elevated in a wide variety of tumors. In many cancers, dysfunctional expression of SOX11 has been correlated with increased cancer cell survival, inhibited cell differentiation, and tumor progression through the induction of metastasis and angiogenesis. Nevertheless, in a limited number of malignancies, SOX11 has also been identified to function as a tumor suppressor. Herein, we review the correlation between the expression of SOX11 and tumor behaviors. We also summarize the mechanisms underlying the regulation of SOX11 expression and activity in pathological conditions. In particular, we focus on the pathological processes of cancer targeted by SOX11 and discuss whether SOX11 is protective or detrimental during tumor progression. Moreover, SOX11 is highlighted as a clinical biomarker for the diagnosis and prognosis of various human cancer. The information reviewed here should assist in future experimental designs and emphasize the potential of SOX11 as a therapeutic target for cancer." @default.
- W2948656340 created "2019-06-14" @default.
- W2948656340 creator A5000910498 @default.
- W2948656340 creator A5004283796 @default.
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- W2948656340 creator A5017440247 @default.
- W2948656340 creator A5017608178 @default.
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- W2948656340 creator A5049692788 @default.
- W2948656340 creator A5071803801 @default.
- W2948656340 creator A5086544897 @default.
- W2948656340 creator A5089312560 @default.
- W2948656340 date "2019-01-01" @default.
- W2948656340 modified "2023-10-16" @default.
- W2948656340 title "SOX11: friend or foe in tumor prevention and carcinogenesis?" @default.
- W2948656340 cites W128803419 @default.
- W2948656340 cites W131355182 @default.
- W2948656340 cites W144423133 @default.
- W2948656340 cites W1552454396 @default.
- W2948656340 cites W1574069719 @default.
- W2948656340 cites W1584207785 @default.
- W2948656340 cites W1599619034 @default.
- W2948656340 cites W1632996825 @default.
- W2948656340 cites W1783580437 @default.
- W2948656340 cites W1834505123 @default.
- W2948656340 cites W184563540 @default.
- W2948656340 cites W1873594900 @default.
- W2948656340 cites W1961928125 @default.
- W2948656340 cites W1964491910 @default.
- W2948656340 cites W1965262464 @default.
- W2948656340 cites W1969125125 @default.
- W2948656340 cites W1970854602 @default.
- W2948656340 cites W1971253093 @default.
- W2948656340 cites W1971805648 @default.
- W2948656340 cites W1974807505 @default.
- W2948656340 cites W1975332071 @default.
- W2948656340 cites W1977889814 @default.
- W2948656340 cites W1980480652 @default.
- W2948656340 cites W1985701920 @default.
- W2948656340 cites W1986022087 @default.
- W2948656340 cites W1987772150 @default.
- W2948656340 cites W1988197673 @default.
- W2948656340 cites W1989625297 @default.
- W2948656340 cites W1989700029 @default.
- W2948656340 cites W1992503939 @default.
- W2948656340 cites W1995541025 @default.
- W2948656340 cites W1997023365 @default.
- W2948656340 cites W1999599951 @default.
- W2948656340 cites W2001108678 @default.
- W2948656340 cites W2001461804 @default.
- W2948656340 cites W2001566685 @default.
- W2948656340 cites W2001618037 @default.
- W2948656340 cites W2003773799 @default.
- W2948656340 cites W2004279423 @default.
- W2948656340 cites W2006031664 @default.
- W2948656340 cites W2006778392 @default.
- W2948656340 cites W2008209085 @default.
- W2948656340 cites W2010977664 @default.
- W2948656340 cites W2011520135 @default.
- W2948656340 cites W2013246689 @default.
- W2948656340 cites W2014104051 @default.
- W2948656340 cites W2017271867 @default.
- W2948656340 cites W2020342155 @default.
- W2948656340 cites W2022584463 @default.
- W2948656340 cites W2023395045 @default.
- W2948656340 cites W2023714700 @default.
- W2948656340 cites W2024040061 @default.
- W2948656340 cites W2024304348 @default.
- W2948656340 cites W2029372290 @default.
- W2948656340 cites W2029940110 @default.
- W2948656340 cites W2033587273 @default.
- W2948656340 cites W2035522955 @default.
- W2948656340 cites W2037483439 @default.
- W2948656340 cites W2040999364 @default.
- W2948656340 cites W2044929234 @default.
- W2948656340 cites W2044993853 @default.
- W2948656340 cites W2048461547 @default.
- W2948656340 cites W2049646321 @default.
- W2948656340 cites W2052750156 @default.
- W2948656340 cites W2054981930 @default.
- W2948656340 cites W2059030354 @default.
- W2948656340 cites W2059176488 @default.
- W2948656340 cites W2060766609 @default.
- W2948656340 cites W2063852280 @default.
- W2948656340 cites W2067288339 @default.
- W2948656340 cites W2068098232 @default.
- W2948656340 cites W2068741167 @default.
- W2948656340 cites W2070405645 @default.
- W2948656340 cites W2072140458 @default.
- W2948656340 cites W2073717167 @default.
- W2948656340 cites W2073910238 @default.
- W2948656340 cites W2073929221 @default.
- W2948656340 cites W2076907721 @default.
- W2948656340 cites W2079034149 @default.
- W2948656340 cites W2080833200 @default.
- W2948656340 cites W2082946974 @default.
- W2948656340 cites W2085253725 @default.
- W2948656340 cites W2086320165 @default.