Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948659925> ?p ?o ?g. }
- W2948659925 abstract "The evolutionary conserved Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is one of the crucial multiprotein complexes that facilitates endosomal recycling of transmembrane proteins. Defects in WASH components have been associated with inherited developmental and neurological disorders in humans. Here, we show that hepatic ablation of the WASH component Washc1 in chow-fed mice increases plasma concentrations of cholesterol in both LDLs and HDLs, without affecting hepatic cholesterol content, hepatic cholesterol synthesis, biliary cholesterol excretion, or hepatic bile acid metabolism. Elevated plasma LDL cholesterol was related to reduced hepatocytic surface levels of the LDL receptor (LDLR) and the LDLR-related protein LRP1. Hepatic WASH ablation also reduced the surface levels of scavenger receptor class B type I and, concomitantly, selective uptake of HDL cholesterol into the liver. Furthermore, we found that WASHC1 deficiency increases LDLR proteolysis by the inducible degrader of LDLR, but does not affect proprotein convertase subtilisin/kexin type 9-mediated LDLR degradation. Remarkably, however, loss of hepatic WASHC1 may sensitize LDLR for proprotein convertase subtilisin/kexin type 9-induced degradation. Altogether, these findings identify the WASH complex as a regulator of LDL as well as HDL metabolism and provide in vivo evidence for endosomal trafficking of scavenger receptor class B type I in hepatocytes." @default.
- W2948659925 created "2019-06-14" @default.
- W2948659925 creator A5003398987 @default.
- W2948659925 creator A5005803435 @default.
- W2948659925 creator A5013598309 @default.
- W2948659925 creator A5027046285 @default.
- W2948659925 creator A5028624448 @default.
- W2948659925 creator A5031086317 @default.
- W2948659925 creator A5032174537 @default.
- W2948659925 creator A5037879493 @default.
- W2948659925 creator A5042911773 @default.
- W2948659925 creator A5045355558 @default.
- W2948659925 creator A5052976856 @default.
- W2948659925 creator A5055768780 @default.
- W2948659925 creator A5056880379 @default.
- W2948659925 creator A5061103675 @default.
- W2948659925 creator A5072637890 @default.
- W2948659925 creator A5073617969 @default.
- W2948659925 creator A5078422504 @default.
- W2948659925 creator A5080426319 @default.
- W2948659925 creator A5085204923 @default.
- W2948659925 date "2019-06-06" @default.
- W2948659925 modified "2023-10-13" @default.
- W2948659925 title "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance" @default.
- W2948659925 cites W1512559452 @default.
- W2948659925 cites W1518331340 @default.
- W2948659925 cites W1578152528 @default.
- W2948659925 cites W1965937044 @default.
- W2948659925 cites W1968153823 @default.
- W2948659925 cites W1968578345 @default.
- W2948659925 cites W1982307380 @default.
- W2948659925 cites W1985170971 @default.
- W2948659925 cites W1991752238 @default.
- W2948659925 cites W2007740137 @default.
- W2948659925 cites W2010847653 @default.
- W2948659925 cites W2011833777 @default.
- W2948659925 cites W2025382042 @default.
- W2948659925 cites W2027938923 @default.
- W2948659925 cites W2032793177 @default.
- W2948659925 cites W2039333617 @default.
- W2948659925 cites W2041324378 @default.
- W2948659925 cites W2042725827 @default.
- W2948659925 cites W2051117863 @default.
- W2948659925 cites W2054883747 @default.
- W2948659925 cites W2055714926 @default.
- W2948659925 cites W2055729264 @default.
- W2948659925 cites W2056411372 @default.
- W2948659925 cites W2061076810 @default.
- W2948659925 cites W2063034857 @default.
- W2948659925 cites W2066978303 @default.
- W2948659925 cites W2067089828 @default.
- W2948659925 cites W2069385307 @default.
- W2948659925 cites W2071885555 @default.
- W2948659925 cites W2077942032 @default.
- W2948659925 cites W2082011949 @default.
- W2948659925 cites W2083088625 @default.
- W2948659925 cites W2083446323 @default.
- W2948659925 cites W2083930160 @default.
- W2948659925 cites W2093099491 @default.
- W2948659925 cites W2094539919 @default.
- W2948659925 cites W2099472310 @default.
- W2948659925 cites W2102161788 @default.
- W2948659925 cites W2103090750 @default.
- W2948659925 cites W2104095808 @default.
- W2948659925 cites W2110245801 @default.
- W2948659925 cites W2114343361 @default.
- W2948659925 cites W2115801316 @default.
- W2948659925 cites W2116823037 @default.
- W2948659925 cites W2117011155 @default.
- W2948659925 cites W2117349394 @default.
- W2948659925 cites W2123685783 @default.
- W2948659925 cites W2134944475 @default.
- W2948659925 cites W2135089070 @default.
- W2948659925 cites W2145828144 @default.
- W2948659925 cites W2149360857 @default.
- W2948659925 cites W2152311269 @default.
- W2948659925 cites W2159712974 @default.
- W2948659925 cites W2161159517 @default.
- W2948659925 cites W2164276007 @default.
- W2948659925 cites W2164390539 @default.
- W2948659925 cites W2165021820 @default.
- W2948659925 cites W2168403456 @default.
- W2948659925 cites W2181693634 @default.
- W2948659925 cites W2186116672 @default.
- W2948659925 cites W2257637313 @default.
- W2948659925 cites W2296190881 @default.
- W2948659925 cites W2345206408 @default.
- W2948659925 cites W2611982385 @default.
- W2948659925 cites W2663610293 @default.
- W2948659925 cites W2754145575 @default.
- W2948659925 cites W2786479690 @default.
- W2948659925 cites W2789459269 @default.
- W2948659925 cites W2802729377 @default.
- W2948659925 cites W2810895029 @default.
- W2948659925 cites W2885672643 @default.
- W2948659925 cites W2890393959 @default.
- W2948659925 cites W2900182380 @default.
- W2948659925 cites W4236254228 @default.
- W2948659925 doi "https://doi.org/10.1172/jci.insight.126462" @default.
- W2948659925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6629119" @default.