Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948748515> ?p ?o ?g. }
- W2948748515 abstract "In children under 5, a hemoglobin (Hb) cutoff of 11 g/dL is recommended by the World Health Organization to define anemia, yet few studies have examined whether this cut point accurately coincides with negative functional consequences. This systematic review and meta-analysis of iron intervention and observational studies aimed to clarify the consequences of low Hb concentration in children under age 5 years on growth, development, and chronic disease (functional outcomes) across the full range of Hb values. A literature search returned 5049 studies; of these, 56 intervention and 20 observational studies fit the inclusion criteria. Among iron supplementation trials, a metaregression indicated significant associations between intervention effects on Hb and their effects on motor and mental development. For each 1 standard deviation (SD) increase in Hb, motor scores increased by 0.28 SD and mental scores increased by 0.24 SD. Iron supplementation trials among children with lower Hb concentrations at baseline showed stronger associations between their effects on Hb and their effects on mental development (P-interaction = 0.008). Heterogeneity among observational studies precluded calculation of pooled associations between Hb and functional outcomes. Available evidence was not able to establish an inflection point at which decreasing Hb begins to be associated with negative functional outcomes. Future research is needed to examine associations of Hb with growth and development in populations with varying levels of Hb, inflammation, and in different ages and settings." @default.
- W2948748515 created "2019-06-14" @default.
- W2948748515 creator A5047561190 @default.
- W2948748515 creator A5052592040 @default.
- W2948748515 creator A5055192912 @default.
- W2948748515 creator A5056620560 @default.
- W2948748515 creator A5058083719 @default.
- W2948748515 creator A5083587747 @default.
- W2948748515 date "2019-06-03" @default.
- W2948748515 modified "2023-10-10" @default.
- W2948748515 title "Effects of increased hemoglobin on child growth, development, and disease: a systematic review and meta‐analysis" @default.
- W2948748515 cites W1576710628 @default.
- W2948748515 cites W1796461077 @default.
- W2948748515 cites W1822988364 @default.
- W2948748515 cites W1876096770 @default.
- W2948748515 cites W1880884476 @default.
- W2948748515 cites W1892690757 @default.
- W2948748515 cites W1896227269 @default.
- W2948748515 cites W1905191103 @default.
- W2948748515 cites W1923175740 @default.
- W2948748515 cites W1935810591 @default.
- W2948748515 cites W1937548549 @default.
- W2948748515 cites W1953299051 @default.
- W2948748515 cites W1970081375 @default.
- W2948748515 cites W1975972276 @default.
- W2948748515 cites W1976908756 @default.
- W2948748515 cites W1979423827 @default.
- W2948748515 cites W1996374563 @default.
- W2948748515 cites W1997535227 @default.
- W2948748515 cites W1999316881 @default.
- W2948748515 cites W1999569455 @default.
- W2948748515 cites W2003406241 @default.
- W2948748515 cites W2013574120 @default.
- W2948748515 cites W2016807528 @default.
- W2948748515 cites W2018588708 @default.
- W2948748515 cites W2018847448 @default.
- W2948748515 cites W2028965954 @default.
- W2948748515 cites W2035537546 @default.
- W2948748515 cites W2037621062 @default.
- W2948748515 cites W2044049186 @default.
- W2948748515 cites W2050086235 @default.
- W2948748515 cites W2061578832 @default.
- W2948748515 cites W2065504854 @default.
- W2948748515 cites W2077996034 @default.
- W2948748515 cites W2078171907 @default.
- W2948748515 cites W2079517651 @default.
- W2948748515 cites W2081005081 @default.
- W2948748515 cites W2086214452 @default.
- W2948748515 cites W2090517766 @default.
- W2948748515 cites W2092984166 @default.
- W2948748515 cites W2096944151 @default.
- W2948748515 cites W2100846803 @default.
- W2948748515 cites W2104782717 @default.
- W2948748515 cites W2106463570 @default.
- W2948748515 cites W2106930941 @default.
- W2948748515 cites W2111761204 @default.
- W2948748515 cites W2121793806 @default.
- W2948748515 cites W2123704440 @default.
- W2948748515 cites W2125661115 @default.
- W2948748515 cites W2128017668 @default.
- W2948748515 cites W2128986921 @default.
- W2948748515 cites W2130963028 @default.
- W2948748515 cites W2131331708 @default.
- W2948748515 cites W2132087610 @default.
- W2948748515 cites W2137593095 @default.
- W2948748515 cites W2141361864 @default.
- W2948748515 cites W2143964697 @default.
- W2948748515 cites W2144393519 @default.
- W2948748515 cites W2144677011 @default.
- W2948748515 cites W2147290448 @default.
- W2948748515 cites W2148343571 @default.
- W2948748515 cites W2150483642 @default.
- W2948748515 cites W2155706250 @default.
- W2948748515 cites W2155746491 @default.
- W2948748515 cites W2159203238 @default.
- W2948748515 cites W2159297940 @default.
- W2948748515 cites W2160640463 @default.
- W2948748515 cites W2161669372 @default.
- W2948748515 cites W2163472591 @default.
- W2948748515 cites W2163986107 @default.
- W2948748515 cites W2170892587 @default.
- W2948748515 cites W2171112462 @default.
- W2948748515 cites W2173734217 @default.
- W2948748515 cites W2179663758 @default.
- W2948748515 cites W2289565648 @default.
- W2948748515 cites W2290376272 @default.
- W2948748515 cites W2294794444 @default.
- W2948748515 cites W2307640647 @default.
- W2948748515 cites W2317114420 @default.
- W2948748515 cites W2329835675 @default.
- W2948748515 cites W2338436964 @default.
- W2948748515 cites W2546882876 @default.
- W2948748515 cites W2594735259 @default.
- W2948748515 cites W2608423256 @default.
- W2948748515 cites W2619535936 @default.
- W2948748515 cites W2757071974 @default.
- W2948748515 cites W2768140967 @default.
- W2948748515 cites W2784509684 @default.
- W2948748515 cites W2808302672 @default.
- W2948748515 cites W2810518819 @default.