Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948774471> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2948774471 endingPage "71" @default.
- W2948774471 startingPage "67" @default.
- W2948774471 abstract "Hyperuricemia has been implicated in the pathogenesis and complications of cardiovascular diseases with associated elevated oxidant events. There is evidence that excessive salt intake results in cardiometabolic disturbances but the mechanism is elusive. Also, Stigma maydis (corn silk) is noted for its antioxidant properties among other beneficial roles. This study, therefore, aimed to establish the effect of high-salt diet (SD) on uric acid (UA) production and the role of S. maydis in salt-induced phenotypes. Four groups of randomly selected rats (n = 5) were fed with normal rat feed, corn silk extract (500 mg/kg), SD (8%) and corn silk extract plus high-salt feed. After 6 weeks of the experimental procedure, each animal was anesthetized by exposure to chloroform vapor and blood samples collected by cardiac puncture. Data were expressed in means ± SEM and p values <0.05 were accepted as significant. SD resulted in reduced plasma superoxide dismutase (SOD), nitric oxide (NO), and glutathione peroxidase (GPx) but not endothelial nitric oxide synthase. Also, plasma UA and vascular cell adhesion molecule-1 (VCAM-1) increased in the SD group compared with control. However, S. maydis extract in the SD-exposed group increased NO and GPx and not SOD. Also, S. maydis extract attenuated UA and VCAM-1. In conclusion, high-salt intake may initiate deleterious cardiovascular events through UA-dependent mechanism and S. maydis extract has therapeutic potential in high-salt–induced oxidative damage and/or UA-dependent endothelial pathologies." @default.
- W2948774471 created "2019-06-14" @default.
- W2948774471 creator A5028556364 @default.
- W2948774471 creator A5033775593 @default.
- W2948774471 creator A5059689778 @default.
- W2948774471 creator A5079620746 @default.
- W2948774471 date "2020-01-01" @default.
- W2948774471 modified "2023-10-15" @default.
- W2948774471 title "Uric acid is a key player in salt-induced endothelial dysfunction: the therapeutic role of<i>Stigma maydis</i>(corn silk) extract" @default.
- W2948774471 cites W1508633825 @default.
- W2948774471 cites W1978771034 @default.
- W2948774471 cites W1993021196 @default.
- W2948774471 cites W2013458793 @default.
- W2948774471 cites W2015960883 @default.
- W2948774471 cites W2035741449 @default.
- W2948774471 cites W2056045638 @default.
- W2948774471 cites W2065475689 @default.
- W2948774471 cites W2065486513 @default.
- W2948774471 cites W2070022026 @default.
- W2948774471 cites W2071556811 @default.
- W2948774471 cites W2072910116 @default.
- W2948774471 cites W2095535221 @default.
- W2948774471 cites W2104712114 @default.
- W2948774471 cites W2106362601 @default.
- W2948774471 cites W2117565014 @default.
- W2948774471 cites W2118232192 @default.
- W2948774471 cites W2118913197 @default.
- W2948774471 cites W2123162884 @default.
- W2948774471 cites W2144308706 @default.
- W2948774471 cites W2146378769 @default.
- W2948774471 cites W2147993424 @default.
- W2948774471 cites W2151079632 @default.
- W2948774471 cites W2153058053 @default.
- W2948774471 cites W2178097068 @default.
- W2948774471 cites W2511586310 @default.
- W2948774471 cites W2912538680 @default.
- W2948774471 doi "https://doi.org/10.1139/apnm-2018-0849" @default.
- W2948774471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31158322" @default.
- W2948774471 hasPublicationYear "2020" @default.
- W2948774471 type Work @default.
- W2948774471 sameAs 2948774471 @default.
- W2948774471 citedByCount "10" @default.
- W2948774471 countsByYear W29487744712019 @default.
- W2948774471 countsByYear W29487744712020 @default.
- W2948774471 countsByYear W29487744712021 @default.
- W2948774471 countsByYear W29487744712022 @default.
- W2948774471 countsByYear W29487744712023 @default.
- W2948774471 crossrefType "journal-article" @default.
- W2948774471 hasAuthorship W2948774471A5028556364 @default.
- W2948774471 hasAuthorship W2948774471A5033775593 @default.
- W2948774471 hasAuthorship W2948774471A5059689778 @default.
- W2948774471 hasAuthorship W2948774471A5079620746 @default.
- W2948774471 hasConcept C126322002 @default.
- W2948774471 hasConcept C16685009 @default.
- W2948774471 hasConcept C185592680 @default.
- W2948774471 hasConcept C2775838275 @default.
- W2948774471 hasConcept C2778004101 @default.
- W2948774471 hasConcept C2778206080 @default.
- W2948774471 hasConcept C2779881121 @default.
- W2948774471 hasConcept C2780972559 @default.
- W2948774471 hasConcept C31903555 @default.
- W2948774471 hasConcept C519581460 @default.
- W2948774471 hasConcept C55493867 @default.
- W2948774471 hasConcept C71924100 @default.
- W2948774471 hasConcept C98274493 @default.
- W2948774471 hasConceptScore W2948774471C126322002 @default.
- W2948774471 hasConceptScore W2948774471C16685009 @default.
- W2948774471 hasConceptScore W2948774471C185592680 @default.
- W2948774471 hasConceptScore W2948774471C2775838275 @default.
- W2948774471 hasConceptScore W2948774471C2778004101 @default.
- W2948774471 hasConceptScore W2948774471C2778206080 @default.
- W2948774471 hasConceptScore W2948774471C2779881121 @default.
- W2948774471 hasConceptScore W2948774471C2780972559 @default.
- W2948774471 hasConceptScore W2948774471C31903555 @default.
- W2948774471 hasConceptScore W2948774471C519581460 @default.
- W2948774471 hasConceptScore W2948774471C55493867 @default.
- W2948774471 hasConceptScore W2948774471C71924100 @default.
- W2948774471 hasConceptScore W2948774471C98274493 @default.
- W2948774471 hasIssue "1" @default.
- W2948774471 hasLocation W29487744711 @default.
- W2948774471 hasLocation W29487744712 @default.
- W2948774471 hasOpenAccess W2948774471 @default.
- W2948774471 hasPrimaryLocation W29487744711 @default.
- W2948774471 hasRelatedWork W2006834589 @default.
- W2948774471 hasRelatedWork W2009239410 @default.
- W2948774471 hasRelatedWork W2038106901 @default.
- W2948774471 hasRelatedWork W2074100616 @default.
- W2948774471 hasRelatedWork W2400723190 @default.
- W2948774471 hasRelatedWork W2415428995 @default.
- W2948774471 hasRelatedWork W3023818513 @default.
- W2948774471 hasRelatedWork W302992813 @default.
- W2948774471 hasRelatedWork W4386241018 @default.
- W2948774471 hasRelatedWork W590771688 @default.
- W2948774471 hasVolume "45" @default.
- W2948774471 isParatext "false" @default.
- W2948774471 isRetracted "false" @default.
- W2948774471 magId "2948774471" @default.
- W2948774471 workType "article" @default.