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- W2948776670 abstract "Abstract During stress, prompt export of stress-inducible transcripts is critical for cell survival. Here, we characterize a function of the SAGA (Spt-Ada-Gcn5 acetyltransferase) deubiquitylating module (DUBm) in monitoring messenger ribonucleoprotein (mRNP) biogenesis to regulate non-canonical mRNA export of stress-inducible transcripts. Our genetic and biochemical analyses suggest that there is a functional relationship between Sgf73p of DUBm and the essential mRNA export factor, Yra1p. Under physiological conditions, Sgf73p is critical for the proper chromatin localization and RNA binding of Yra1p, while also quality controlling the biogenesis of mRNPs in conjunction with the nuclear exosome exonuclease, Rrp6p. Under environmental stress, when immediate transport of stress-inducible transcripts is imperative, Sgf73p facilitates the bypass of canonical surveillance and promotes the timely export of necessary transcripts. Overall, our results show that the Sgf73p-mediated plasticity of gene expression is important for the ability of cells to tolerate stress and regulate proteostasis to survive under environmental uncertainty." @default.
- W2948776670 created "2019-06-14" @default.
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- W2948776670 date "2019-06-05" @default.
- W2948776670 modified "2023-09-27" @default.
- W2948776670 title "SAGA DUBm-mediated surveillance regulates prompt export of stress-inducible transcripts for proteostasis" @default.
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- W2948776670 doi "https://doi.org/10.1038/s41467-019-10350-6" @default.
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