Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948776902> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2948776902 endingPage "578" @default.
- W2948776902 startingPage "574" @default.
- W2948776902 abstract "For the use of immunotherapy in metastatic non-small cell lung cancer (NSCLC), the NCCN Guidelines for NSCLC reflect the importance of assessing levels of PD-L1 expression to determine the best use of PD-1/PD-L1 inhibitors, whether alone or in combination with chemotherapy. Patients who lack a driver mutation and have tumor PD-L1 expression ≥50% are recommended to receive single-agent pembrolizumab, although combining with carboplatin/pemetrexed is also a reasonable choice, especially if there is higher burden of disease. For tumors with PD-L1 expression <50%, it is important to distinguish between nonsquamous and squamous cell carcinoma (SCC). For patients with non-SCC disease, pembrolizumab + carboplatin/pemetrexed is preferred. Alternately, a 4-drug regimen of carboplatin/paclitaxel/bevacizumab/atezolizumab is reasonable, especially for patients ineligible for pemetrexed. In patients with SCC, carboplatin + paclitaxel or nab-paclitaxel with pembrolizumab is a category 1 recommendation. Tumor mutational burden is emerging as a biomarker for efficacy but is not yet ready to be used in patient selection. Optimal management of the unique toxicities associated with immunotherapy, which can be more frequent with these combinations, is also critical for good outcomes." @default.
- W2948776902 created "2019-06-14" @default.
- W2948776902 creator A5038165740 @default.
- W2948776902 creator A5055548058 @default.
- W2948776902 date "2019-05-01" @default.
- W2948776902 modified "2023-09-29" @default.
- W2948776902 title "NCCN Guidelines Updates: New Immunotherapy Strategies for Improving Outcomes in Non-Small Cell Lung Cancer." @default.
- W2948776902 cites W2527905628 @default.
- W2948776902 cites W2594102731 @default.
- W2948776902 cites W2635951006 @default.
- W2948776902 cites W2753065806 @default.
- W2948776902 cites W2777461561 @default.
- W2948776902 cites W2797675588 @default.
- W2948776902 cites W2806388842 @default.
- W2948776902 cites W2884995493 @default.
- W2948776902 cites W2886963239 @default.
- W2948776902 cites W2890663189 @default.
- W2948776902 cites W2892640821 @default.
- W2948776902 cites W2910245285 @default.
- W2948776902 doi "https://doi.org/10.6004/jnccn.2019.5005" @default.
- W2948776902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31117034" @default.
- W2948776902 hasPublicationYear "2019" @default.
- W2948776902 type Work @default.
- W2948776902 sameAs 2948776902 @default.
- W2948776902 citedByCount "35" @default.
- W2948776902 countsByYear W29487769022019 @default.
- W2948776902 countsByYear W29487769022020 @default.
- W2948776902 countsByYear W29487769022021 @default.
- W2948776902 countsByYear W29487769022022 @default.
- W2948776902 countsByYear W29487769022023 @default.
- W2948776902 crossrefType "posted-content" @default.
- W2948776902 hasAuthorship W2948776902A5038165740 @default.
- W2948776902 hasAuthorship W2948776902A5055548058 @default.
- W2948776902 hasConcept C121608353 @default.
- W2948776902 hasConcept C126322002 @default.
- W2948776902 hasConcept C143998085 @default.
- W2948776902 hasConcept C2775949291 @default.
- W2948776902 hasConcept C2776256026 @default.
- W2948776902 hasConcept C2776694085 @default.
- W2948776902 hasConcept C2777240266 @default.
- W2948776902 hasConcept C2777701055 @default.
- W2948776902 hasConcept C2777802072 @default.
- W2948776902 hasConcept C2778239845 @default.
- W2948776902 hasConcept C2780030458 @default.
- W2948776902 hasConcept C2780057760 @default.
- W2948776902 hasConcept C2781413609 @default.
- W2948776902 hasConcept C2781451048 @default.
- W2948776902 hasConcept C71924100 @default.
- W2948776902 hasConceptScore W2948776902C121608353 @default.
- W2948776902 hasConceptScore W2948776902C126322002 @default.
- W2948776902 hasConceptScore W2948776902C143998085 @default.
- W2948776902 hasConceptScore W2948776902C2775949291 @default.
- W2948776902 hasConceptScore W2948776902C2776256026 @default.
- W2948776902 hasConceptScore W2948776902C2776694085 @default.
- W2948776902 hasConceptScore W2948776902C2777240266 @default.
- W2948776902 hasConceptScore W2948776902C2777701055 @default.
- W2948776902 hasConceptScore W2948776902C2777802072 @default.
- W2948776902 hasConceptScore W2948776902C2778239845 @default.
- W2948776902 hasConceptScore W2948776902C2780030458 @default.
- W2948776902 hasConceptScore W2948776902C2780057760 @default.
- W2948776902 hasConceptScore W2948776902C2781413609 @default.
- W2948776902 hasConceptScore W2948776902C2781451048 @default.
- W2948776902 hasConceptScore W2948776902C71924100 @default.
- W2948776902 hasIssue "5.5" @default.
- W2948776902 hasLocation W29487769021 @default.
- W2948776902 hasOpenAccess W2948776902 @default.
- W2948776902 hasPrimaryLocation W29487769021 @default.
- W2948776902 hasRelatedWork W2763469204 @default.
- W2948776902 hasRelatedWork W2914160668 @default.
- W2948776902 hasRelatedWork W2948776902 @default.
- W2948776902 hasRelatedWork W2948845624 @default.
- W2948776902 hasRelatedWork W3023819640 @default.
- W2948776902 hasRelatedWork W3046351302 @default.
- W2948776902 hasRelatedWork W3089162555 @default.
- W2948776902 hasRelatedWork W3106063606 @default.
- W2948776902 hasRelatedWork W3215044659 @default.
- W2948776902 hasRelatedWork W4252112718 @default.
- W2948776902 hasVolume "17" @default.
- W2948776902 isParatext "false" @default.
- W2948776902 isRetracted "false" @default.
- W2948776902 magId "2948776902" @default.
- W2948776902 workType "article" @default.