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- W2948780281 startingPage "583" @default.
- W2948780281 abstract "Mitochondrial damage precedes histopathological abnormalities in diabetic retinopathy (DR). Retinal endothelial cells (REC) have the highest level of Acid Sphingomyelinase (ASM) expression in the retina and the increase in ASM activity and ceramide production were shown to promote diabetes-induced pro-inflammatory and pro-apoptotic changes in the retina and REC. The role of diabetes-induced increase in ASM and ceramide production in mitochondrial damage in the retina and REC is not known." @default.
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- W2948780281 date "2019-06-01" @default.
- W2948780281 modified "2023-09-25" @default.
- W2948780281 title "583-P: Increase in Mitochondrial Ceramide Contributes to Diabetes-Induced Retinal Endothelial Cell Damage" @default.
- W2948780281 doi "https://doi.org/10.2337/db19-583-p" @default.
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