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- W2948785574 endingPage "345" @default.
- W2948785574 startingPage "323" @default.
- W2948785574 abstract "β-Lactones are four-membered heterocycles with high ring-strain, electrophilicity and reactivity. The majority of β-lactone natural products have been isolated from Actinobacteria and fungi, although they are found in all domains of life including higher plants and animals. Over 30 core scaffolds of β-lactone natural products have been described to date, many of which possess potent medicinal properties. The weight loss agent, orlistat, is currently the only approved β-lactone drug on the market, but other candidates, including salinosporamide A, have entered clinical trials. Since 2017, major breakthroughs have been made in understanding the biosynthesis of β-lactone compounds including obafluorin and the cystargolides. In this article we will cover recent developments in β-lactone ring formation in the context of natural products. Additionally, we will compare and contrast enzymatic routes to β-lactones with β-lactams and other four-membered rings." @default.
- W2948785574 created "2019-06-14" @default.
- W2948785574 creator A5004798651 @default.
- W2948785574 creator A5054046029 @default.
- W2948785574 date "2020-01-01" @default.
- W2948785574 modified "2023-10-18" @default.
- W2948785574 title "Rings of Power: Enzymatic Routes to β-Lactones" @default.
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