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- W2948803424 abstract "Abstract— Objectives: The aim of this study was to investigate the response of human skeletal muscle myoblasts to therapeutic doses of X-irradiation.Methods: Myoblasts was established via skeletal muscle biopsies which irradiated in vitro by x-ray at doses 3, 5 and 7 Gy. Two effects of radiation were measured (acute effect after 24h and long term effect after 72h). Acute effect was monitored by interleukin-6 release, while long term effect was monitored by measuring the proliferation capacity and cell death.Results: When comparing the non-irradiated control and cells processed with inhibitor of cell proliferation Ara C, myoblast proliferation reduced in 72h post-radiation, this change was significant with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity showed increased activity after exposure to x-rays. The acute reaction of myoblasts to lower doses of irradiation (3 and 5 Gy.) was reduced secretion of constitutive interleukin-6.Conclusion: The current study approved that there was positive response of human skeletal muscle myoblasts to therapeutic doses of X-irradiation.." @default.
- W2948803424 created "2019-06-14" @default.
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- W2948803424 date "2016-06-01" @default.
- W2948803424 modified "2023-09-25" @default.
- W2948803424 title "استجابة خلايا العضلات الجزعية لأشعة اكس العلاجية / Response of Human Myoblasts to Therapeutic Doses of X-irradiation" @default.
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