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• W2948803755 abstract "Abstract The UV-inducible pili system of Sulfolobales (Ups) mediates the formation of species-specific cellular aggregates. Within these aggregates, cells exchange DNA in order to repair DNA double strand breaks via homologous recombination. Substitution of the S. acidocaldarius pilin subunits UpsA and UpsB with their homologs from Sulfolobus tokodaii showed that these subunits facilitate species-specific aggregation. A region of low conservation within the UpsA homologs is primarily important for this specificity. Aggregation assays in the presence of different sugars showed the importance of N -glycosylation in the recognition process. In addition, the N -glycan decorating the S-layer of S. tokodaii is different from the one of S. acidocaldarius . Therefore, each Sulfolobus species seems to have developed a unique UpsA binding pocket and unique N- glycan composition to ensure aggregation and consequently also DNA exchange with cells from only the same species, which is essential for DNA repair by homologous recombination. Importance Type IV pili can be found on the cell surface of many archaea and bacteria where they play important roles in different processes. The Ups-pili from the crenarchaeal Sulfolobales species are essential in establishing species-specific mating partners, ensuring genome stability. With this work, we show that different Sulfolobus species have species-specific regions in their Ups-pilin subunits, which allow them to interact only with cells from the same species. Additionally, different Sulfolobus species all have unique S-layer N -glycosylation patterns. We propose that the unique features of each species allow the recognition of specific mating partners. This knowledge for the first time gives insights into the molecular basis of archaeal self-recognition." @default.
• W2948803755 created "2019-06-14" @default.
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• W2948803755 date "2019-06-08" @default.
• W2948803755 modified "2023-09-23" @default.
• W2948803755 title "Species-specific recognition of Sulfolobales mediated by UV-inducible pili and S-layer glycosylation patterns" @default.
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• W2948803755 doi "https://doi.org/10.1101/663898" @default.
• W2948803755 hasPublicationYear "2019" @default.
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