FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948829265> ?p ?o ?g. }

• W2948829265 endingPage "286" @default.
• W2948829265 startingPage "286" @default.
• W2948829265 abstract "Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA synthesis are regulated by peroxisome proliferator-activated receptor alpha (PPARα). Therefore, it was hypothesized that the tissue accretion of endogenously synthesized DHA could be modified by PPARα.The tissue DHA concentrations and mRNA levels of genes participating in DHA biosynthesis were compared among PPARα homozygous (KO), heterozygous (HZ), and wild type (WT) mice (Exp I), and between WT mice treated with clofibrate (PPARα agonist) or those not treated (Exp II). In ExpII, the expression levels of the proteins associated with DHA function in the brain cortex and retina were also measured. An n3-PUFA depleted/replenished regimen was applied to mitigate the confounding effects of maternal DHA.PPARα ablation reduced the hepatic Acox, Fads1, and Fads2 mRNA levels, as well as the DHA concentration in the liver, but not in the brain cortex. In contrast, PPARα activation increased hepatic Acox, Fads1, Fads2 and Elovl5 mRNA levels, but reduced the DHA concentrations in the liver, retina, and phospholipid of brain cortex, and decreased mRNA and protein levels of the brain-derived neurotrophic factor in brain cortex.LCPUFA enzyme expression was altered by PPARα. Either PPARα deficiency or activation-decreased tissue DHA concentration is a stimulus for further studies to determine the functional significance." @default.
• W2948829265 created "2019-06-14" @default.
• W2948829265 creator A5013246681 @default.
• W2948829265 creator A5014595196 @default.
• W2948829265 creator A5016374614 @default.
• W2948829265 creator A5027302217 @default.
• W2948829265 creator A5036896030 @default.
• W2948829265 creator A5048512121 @default.
• W2948829265 creator A5049414211 @default.
• W2948829265 creator A5079171500 @default.
• W2948829265 date "2019-01-01" @default.
• W2948829265 modified "2023-10-16" @default.
• W2948829265 title "Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice" @default.
• W2948829265 cites W1583498277 @default.
• W2948829265 cites W1597109281 @default.
• W2948829265 cites W1791771324 @default.
• W2948829265 cites W1818048492 @default.
• W2948829265 cites W1831301545 @default.
• W2948829265 cites W1961820026 @default.
• W2948829265 cites W1972859890 @default.
• W2948829265 cites W1974460158 @default.
• W2948829265 cites W1974573492 @default.
• W2948829265 cites W1980744068 @default.
• W2948829265 cites W1982920909 @default.
• W2948829265 cites W1984058728 @default.
• W2948829265 cites W1999394306 @default.
• W2948829265 cites W2000176794 @default.
• W2948829265 cites W2004322550 @default.
• W2948829265 cites W2008557193 @default.
• W2948829265 cites W2024217191 @default.
• W2948829265 cites W2029150533 @default.
• W2948829265 cites W2032456267 @default.
• W2948829265 cites W2036303685 @default.
• W2948829265 cites W2039288277 @default.
• W2948829265 cites W2040354463 @default.
• W2948829265 cites W2046186534 @default.
• W2948829265 cites W2051257128 @default.
• W2948829265 cites W2056872980 @default.
• W2948829265 cites W2066790769 @default.
• W2948829265 cites W2067927862 @default.
• W2948829265 cites W2070934894 @default.
• W2948829265 cites W2076232924 @default.
• W2948829265 cites W2078472811 @default.
• W2948829265 cites W2078672433 @default.
• W2948829265 cites W2092474731 @default.
• W2948829265 cites W2093135493 @default.
• W2948829265 cites W2099363307 @default.
• W2948829265 cites W2116351973 @default.
• W2948829265 cites W2119068792 @default.
• W2948829265 cites W2120830896 @default.
• W2948829265 cites W2124035137 @default.
• W2948829265 cites W2138271889 @default.
• W2948829265 cites W2139103260 @default.
• W2948829265 cites W2146814107 @default.
• W2948829265 cites W2156386840 @default.
• W2948829265 cites W2172099178 @default.
• W2948829265 cites W2186476960 @default.
• W2948829265 cites W2351934060 @default.
• W2948829265 cites W2465441164 @default.
• W2948829265 cites W2550207538 @default.
• W2948829265 cites W2563394429 @default.
• W2948829265 cites W2620615807 @default.
• W2948829265 cites W2738615641 @default.
• W2948829265 cites W2745498368 @default.
• W2948829265 cites W4323238746 @default.
• W2948829265 doi "https://doi.org/10.4162/nrp.2019.13.4.286" @default.
• W2948829265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6669072" @default.
• W2948829265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31388404" @default.
• W2948829265 hasPublicationYear "2019" @default.
• W2948829265 type Work @default.
• W2948829265 sameAs 2948829265 @default.
• W2948829265 citedByCount "5" @default.
• W2948829265 countsByYear W29488292652020 @default.
• W2948829265 countsByYear W29488292652021 @default.
• W2948829265 countsByYear W29488292652022 @default.
• W2948829265 countsByYear W29488292652023 @default.
• W2948829265 crossrefType "journal-article" @default.
• W2948829265 hasAuthorship W2948829265A5013246681 @default.
• W2948829265 hasAuthorship W2948829265A5014595196 @default.
• W2948829265 hasAuthorship W2948829265A5016374614 @default.
• W2948829265 hasAuthorship W2948829265A5027302217 @default.
• W2948829265 hasAuthorship W2948829265A5036896030 @default.
• W2948829265 hasAuthorship W2948829265A5048512121 @default.
• W2948829265 hasAuthorship W2948829265A5049414211 @default.
• W2948829265 hasAuthorship W2948829265A5079171500 @default.
• W2948829265 hasBestOaLocation W29488292652 @default.
• W2948829265 hasConcept C126322002 @default.
• W2948829265 hasConcept C134018914 @default.
• W2948829265 hasConcept C170493617 @default.
• W2948829265 hasConcept C185592680 @default.
• W2948829265 hasConcept C187345961 @default.
• W2948829265 hasConcept C19038510 @default.
• W2948829265 hasConcept C2777171753 @default.
• W2948829265 hasConcept C2778915593 @default.
• W2948829265 hasConcept C543025807 @default.
• W2948829265 hasConcept C55493867 @default.
• W2948829265 hasConcept C71924100 @default.
• W2948829265 hasConcept C86803240 @default.

• next