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- W2948851808 endingPage "e2006223" @default.
- W2948851808 startingPage "e2006223" @default.
- W2948851808 abstract "Neurons receive a large number of active synaptic inputs from their many presynaptic partners across their dendritic tree. However, little is known about how the strengths of individual synapses are controlled in balance with other synapses to effectively encode information while maintaining network homeostasis. This is in part due to the difficulty in assessing the activity of individual synapses with identified afferent and efferent connections for a synapse population in the brain. Here, to gain insights into the basic cellular rules that drive the activity-dependent spatial distribution of pre- and postsynaptic strengths across incoming axons and dendrites, we combine patch-clamp recordings with live-cell imaging of hippocampal pyramidal neurons in dissociated cultures and organotypic slices. Under basal conditions, both pre- and postsynaptic strengths cluster on single dendritic branches according to the identity of the presynaptic neurons, thus highlighting the ability of single dendritic branches to exhibit input specificity. Stimulating a single presynaptic neuron induces input-specific and dendritic branchwise spatial clustering of presynaptic strengths, which accompanies a widespread multiplicative scaling of postsynaptic strengths in dissociated cultures and heterosynaptic plasticity at distant synapses in organotypic slices. Our study provides evidence for a potential homeostatic mechanism by which the rapid changes in global or distant postsynaptic strengths compensate for input-specific presynaptic plasticity." @default.
- W2948851808 created "2019-06-14" @default.
- W2948851808 creator A5061054860 @default.
- W2948851808 creator A5067453029 @default.
- W2948851808 creator A5073132799 @default.
- W2948851808 creator A5073325220 @default.
- W2948851808 date "2019-06-05" @default.
- W2948851808 modified "2023-10-13" @default.
- W2948851808 title "Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites" @default.
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