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• W2948852849 endingPage "292" @default.
• W2948852849 startingPage "271" @default.
• W2948852849 abstract "Traditional prototype development and optimization is a long and costly process. Customization of those products is either very difficult or unfeasible. Healthcare implants are often chosen by the surgeon, much like shoes, for the ‘best fit’. In addition to synthetic implant issues, there is a considerable lack of tissue and organs for transplant. When we consider the development and testing of new drugs, many in vitro models are poor predictors for drug efficacy. Cell and tissue growth on commonly used plastics, in 2 dimensions, may be part of this issue. Looking at drug delivery, the release and stability are often poorly optimized, with controlled drug delivery and release kinetics often unaddressed. In addition to these healthcare related issues, the world is facing increased pressure for resources due to both population growth and standard of living increases. 3D printing and 3D bioprinting offer potential solutions to these problems. There is no doubt that a new era of manufacturing is upon us; 3D printing has revolutionized the way products are made, developed and customized. Chitosan has captured a small area of these fields at 1.1% of total 3D printing and ~4% of bioprinting publications. The open source movement has made the instrumentation, modeling and hardware control software more accessible, further improving the customizability of products. This will also likely increase the number of studies using chitosan. Within the biomedical arena where chitosan and its derivatives have been used, chitosan has found utility across many cell types, including mesenchymal stromal cells and induced pluripotent stem cells, and in modeling tissues such as bone, cartilage and liver. A 3D printed chitosan-based structure was able to record breathing rate, pulse rate, and finger and bicep flexion due to changes in conductivity when compressed. As a biodegradable polymer, chitosan can be added to the list of low resource and low environmental impact 3D printing materials. This chapter focuses on the use of chitosan in 3D printing and bioprinting, highlighting its application in drug delivery and tissue engineering." @default.
• W2948852849 created "2019-06-14" @default.
• W2948852849 creator A5007460215 @default.
• W2948852849 creator A5016786626 @default.
• W2948852849 date "2019-01-01" @default.
• W2948852849 modified "2023-09-26" @default.
• W2948852849 title "Utility of Chitosan for 3D Printing and Bioprinting" @default.
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• W2948852849 doi "https://doi.org/10.1007/978-3-030-16538-3_6" @default.
• W2948852849 hasPublicationYear "2019" @default.

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