Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948860116> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2948860116 abstract "Targeted, controlled, and noninvasive delivery of therapeutics is a major goal of pharmaceutical development. However, few techniques allow imaging and controlled drug release at the cellular level. Herein, a potential targeted drug delivery platform with three imaging reporters has been developed by coupling the magnetic properties of ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) with near infrared fluorescence of Cy5.5 and γ-emissions of 111In that is chelated to a conjugated antibody. This silica-coated iron oxide nanoparticle (SCION) allows for verification of localization, characterization of nearby physiology, and quantification. During each phase of development, the nanoparticles have been characterized for surface charge, structure, optical response, and magnetic properties. Although the size is an advantage for passive delivery, to actively direct SCIONs to a specific location (i.e. epithelial cancers or multiple sclerosis inflammatory foci), various antibodies have been attached to the particle surface. The chelator CHXA”-DTPA was conjugated to antibody for radioisotope labeling. Cell viability, biodistribution, pharmacokinetics, MR, optical, and nuclear imaging studies were conducted. The results presented demonstrate SCION‟s potential for application in cell tracking and liver imaging, as well as its promise in the area of sentinel node imaging. In vivo optical and magnetic resonance imaging of athymic mice given intracutaneous injection of multimodal SCION in the foot pad reveal visualization of the primary draining lymph nodes. Unlike previous techniques, the particle could first be used to characterize lymph nodes by MR, followed by fluorescence identification during surgery, and further histology using its fluorescence and iron content. As currently synthesized, the nanoparticles can be used for diagnostics; however, they can also be developed into a method of thermotherapy. Once the delivery construct is traced to its target location, its superparamagnetic properties can be exploited by the application of an AC magnetic field to heat tissue or activate a drug. Thus, with conjugates of this nanoparticle, it should be possible to target specific tissues, verify localization and then non-invasively activate multimodal therapies using extrinsic fields." @default.
- W2948860116 created "2019-06-14" @default.
- W2948860116 creator A5042390474 @default.
- W2948860116 date "2008-01-01" @default.
- W2948860116 modified "2023-09-26" @default.
- W2948860116 title "Nanomedicine : development of a tri-imageable nanoparticle for diagnostics" @default.
- W2948860116 hasPublicationYear "2008" @default.
- W2948860116 type Work @default.
- W2948860116 sameAs 2948860116 @default.
- W2948860116 citedByCount "0" @default.
- W2948860116 crossrefType "dissertation" @default.
- W2948860116 hasAuthorship W2948860116A5042390474 @default.
- W2948860116 hasConcept C121332964 @default.
- W2948860116 hasConcept C121608353 @default.
- W2948860116 hasConcept C126322002 @default.
- W2948860116 hasConcept C126511603 @default.
- W2948860116 hasConcept C126838900 @default.
- W2948860116 hasConcept C136229726 @default.
- W2948860116 hasConcept C136339569 @default.
- W2948860116 hasConcept C143409427 @default.
- W2948860116 hasConcept C15083742 @default.
- W2948860116 hasConcept C150903083 @default.
- W2948860116 hasConcept C155672457 @default.
- W2948860116 hasConcept C171250308 @default.
- W2948860116 hasConcept C185592680 @default.
- W2948860116 hasConcept C192562407 @default.
- W2948860116 hasConcept C202751555 @default.
- W2948860116 hasConcept C207001950 @default.
- W2948860116 hasConcept C2777807558 @default.
- W2948860116 hasConcept C2778889443 @default.
- W2948860116 hasConcept C2779820397 @default.
- W2948860116 hasConcept C2780212769 @default.
- W2948860116 hasConcept C530470458 @default.
- W2948860116 hasConcept C55493867 @default.
- W2948860116 hasConcept C57477423 @default.
- W2948860116 hasConcept C62520636 @default.
- W2948860116 hasConcept C71924100 @default.
- W2948860116 hasConcept C86803240 @default.
- W2948860116 hasConcept C91881484 @default.
- W2948860116 hasConceptScore W2948860116C121332964 @default.
- W2948860116 hasConceptScore W2948860116C121608353 @default.
- W2948860116 hasConceptScore W2948860116C126322002 @default.
- W2948860116 hasConceptScore W2948860116C126511603 @default.
- W2948860116 hasConceptScore W2948860116C126838900 @default.
- W2948860116 hasConceptScore W2948860116C136229726 @default.
- W2948860116 hasConceptScore W2948860116C136339569 @default.
- W2948860116 hasConceptScore W2948860116C143409427 @default.
- W2948860116 hasConceptScore W2948860116C15083742 @default.
- W2948860116 hasConceptScore W2948860116C150903083 @default.
- W2948860116 hasConceptScore W2948860116C155672457 @default.
- W2948860116 hasConceptScore W2948860116C171250308 @default.
- W2948860116 hasConceptScore W2948860116C185592680 @default.
- W2948860116 hasConceptScore W2948860116C192562407 @default.
- W2948860116 hasConceptScore W2948860116C202751555 @default.
- W2948860116 hasConceptScore W2948860116C207001950 @default.
- W2948860116 hasConceptScore W2948860116C2777807558 @default.
- W2948860116 hasConceptScore W2948860116C2778889443 @default.
- W2948860116 hasConceptScore W2948860116C2779820397 @default.
- W2948860116 hasConceptScore W2948860116C2780212769 @default.
- W2948860116 hasConceptScore W2948860116C530470458 @default.
- W2948860116 hasConceptScore W2948860116C55493867 @default.
- W2948860116 hasConceptScore W2948860116C57477423 @default.
- W2948860116 hasConceptScore W2948860116C62520636 @default.
- W2948860116 hasConceptScore W2948860116C71924100 @default.
- W2948860116 hasConceptScore W2948860116C86803240 @default.
- W2948860116 hasConceptScore W2948860116C91881484 @default.
- W2948860116 hasLocation W29488601161 @default.
- W2948860116 hasOpenAccess W2948860116 @default.
- W2948860116 hasPrimaryLocation W29488601161 @default.
- W2948860116 hasRelatedWork W1517169310 @default.
- W2948860116 hasRelatedWork W169279876 @default.
- W2948860116 hasRelatedWork W1969041393 @default.
- W2948860116 hasRelatedWork W1975267657 @default.
- W2948860116 hasRelatedWork W1989341491 @default.
- W2948860116 hasRelatedWork W2013722826 @default.
- W2948860116 hasRelatedWork W2029778624 @default.
- W2948860116 hasRelatedWork W2035648189 @default.
- W2948860116 hasRelatedWork W2071705233 @default.
- W2948860116 hasRelatedWork W2082300336 @default.
- W2948860116 hasRelatedWork W2164883654 @default.
- W2948860116 hasRelatedWork W2511821073 @default.
- W2948860116 hasRelatedWork W2771228525 @default.
- W2948860116 hasRelatedWork W2790266262 @default.
- W2948860116 hasRelatedWork W2790816643 @default.
- W2948860116 hasRelatedWork W2793657092 @default.
- W2948860116 hasRelatedWork W2883158026 @default.
- W2948860116 hasRelatedWork W2899312102 @default.
- W2948860116 hasRelatedWork W2994965963 @default.
- W2948860116 hasRelatedWork W2782317546 @default.
- W2948860116 isParatext "false" @default.
- W2948860116 isRetracted "false" @default.
- W2948860116 magId "2948860116" @default.
- W2948860116 workType "dissertation" @default.