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- W2948922639 abstract "It is well-known that higher rates of non-severe hypoglycemic episodes (NSHEs) associate with a greater risk of severe hypoglycemic episodes (SHEs) in patients with type 1 diabetes. We investigated whether a similar association existed in patients with type 2 diabetes (T2D). We explored if annual rate of NSHEs was associated with time to first SHE, cardiovascular (CV) death, time to first major adverse CV event (MACE), and all cause death in patients with T2D using data from LEADER, a CV outcomes trial with 9340 patients with T2D.We used a Cox proportional hazards model adjusted for randomized treatment arm, and annual rate of NSHE as a time-dependent covariate with three levels; A: <2 NSHEs per year (reference), B: 2−11 NSHEs, or C: ≥12 NSHEs. Hazard ratios were used to estimate the association between NSHE and each of the outcomes. Higher rates of NSHE were associated with a higher rate of severe hypoglycemia, MACE, CV death, and all-cause death in patients with T2D (Figure); our results suggest that in this T2D population, a high rate of NSHEs may be associated with more harmful outcomes." @default.
- W2948922639 created "2019-06-14" @default.
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- W2948922639 date "2019-06-01" @default.
- W2948922639 modified "2023-09-24" @default.
- W2948922639 title "11-LB: Nonsevere Hypoglycemia Predicts Increased Risk of Subsequent Severe Events in Patients with Type 2 Diabetes" @default.
- W2948922639 doi "https://doi.org/10.2337/db19-11-lb" @default.
- W2948922639 hasPublicationYear "2019" @default.
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