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• W2948924404 abstract "Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, as suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant depression. Preclinical and clinical studies have suggested that serum brain-derived neurotrophic factor (BDNF) levels increase after treatment with serotoninergic antidepressants, but the exact role of BDNF as a biomarker for diagnostic and treatment of major depression is still poorly understood. Here we investigated serum BDNF levels in healthy controls (N = 45) and patients with treatment-resistant depression (N = 28) before (baseline) and 48 h after (D2) a single dose of ayahuasca or placebo. In our sample, baseline serum BDNF levels did not predict major depression and the clinical characteristics of the patients did not predict their BDNF levels. However, at baseline, serum cortisol was a predictor of serum BDNF levels, where lower levels of serum BDNF were detected in a subgroup of subjects with hypocortisolemia. Moreover, at baseline we found a negative correlation between BDNF and serum cortisol in volunteers with eucortisolemia. After treatment (D2) we observed higher BDNF levels in both patients and controls that ingested ayahuasca (N = 35) when compared to placebo (N = 34). Furthermore, at D2 just patients treated with ayahuasca (N = 14), and not with placebo (N = 14), presented a significant negative correlation between serum BDNF levels and depressive symptoms. This is the first double-blind randomized placebo-controlled clinical trial that explored the modulation of BDNF in response to a psychedelic in patients with depression. The results suggest a potential link between the observed antidepressant effects of ayahuasca and changes in serum BDNF, which contributes to the emerging view of using psychedelics as an antidepressant. This trial is registered at http://clinicaltrials.gov (NCT02914769)." @default.
• W2948924404 created "2019-06-14" @default.
• W2948924404 creator A5000955196 @default.
• W2948924404 creator A5007139726 @default.
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• W2948924404 creator A5026360123 @default.
• W2948924404 creator A5039275730 @default.
• W2948924404 creator A5041005999 @default.
• W2948924404 creator A5056388274 @default.
• W2948924404 creator A5087804965 @default.
• W2948924404 creator A5088679759 @default.
• W2948924404 date "2019-06-04" @default.
• W2948924404 modified "2023-10-17" @default.
• W2948924404 title "Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial" @default.
• W2948924404 cites W1430627820 @default.
• W2948924404 cites W146502225 @default.
• W2948924404 cites W1482340405 @default.
• W2948924404 cites W1524557624 @default.
• W2948924404 cites W1529178472 @default.
• W2948924404 cites W1595936241 @default.
• W2948924404 cites W161416703 @default.
• W2948924404 cites W1659146612 @default.
• W2948924404 cites W183123008 @default.
• W2948924404 cites W1965069010 @default.
• W2948924404 cites W1973276415 @default.
• W2948924404 cites W1980053755 @default.
• W2948924404 cites W1990662781 @default.
• W2948924404 cites W1992914052 @default.
• W2948924404 cites W1994377540 @default.
• W2948924404 cites W2000209446 @default.
• W2948924404 cites W2002537642 @default.
• W2948924404 cites W2003982930 @default.
• W2948924404 cites W2007130516 @default.
• W2948924404 cites W2019379291 @default.
• W2948924404 cites W2019808168 @default.
• W2948924404 cites W2023634568 @default.
• W2948924404 cites W2024837798 @default.
• W2948924404 cites W2028786180 @default.
• W2948924404 cites W2035399728 @default.
• W2948924404 cites W2040899392 @default.
• W2948924404 cites W2043283741 @default.
• W2948924404 cites W2055040288 @default.
• W2948924404 cites W2059507131 @default.
• W2948924404 cites W2063839886 @default.
• W2948924404 cites W2068751924 @default.
• W2948924404 cites W2072457730 @default.
• W2948924404 cites W2072848692 @default.
• W2948924404 cites W2076077022 @default.
• W2948924404 cites W2080916058 @default.
• W2948924404 cites W2089198034 @default.
• W2948924404 cites W2092360775 @default.
• W2948924404 cites W2096699969 @default.
• W2948924404 cites W2099749043 @default.
• W2948924404 cites W2101958746 @default.
• W2948924404 cites W2106772049 @default.
• W2948924404 cites W2109737067 @default.
• W2948924404 cites W2110419377 @default.
• W2948924404 cites W2114613490 @default.
• W2948924404 cites W2131823335 @default.
• W2948924404 cites W2133199972 @default.
• W2948924404 cites W2134458928 @default.
• W2948924404 cites W2134697757 @default.
• W2948924404 cites W2137983723 @default.
• W2948924404 cites W2148950534 @default.
• W2948924404 cites W2166347822 @default.
• W2948924404 cites W2167565363 @default.
• W2948924404 cites W2186244073 @default.
• W2948924404 cites W2192903463 @default.
• W2948924404 cites W2285300722 @default.
• W2948924404 cites W2325558246 @default.
• W2948924404 cites W2334324929 @default.
• W2948924404 cites W2336724059 @default.
• W2948924404 cites W2344956345 @default.
• W2948924404 cites W2394347777 @default.
• W2948924404 cites W2414909242 @default.
• W2948924404 cites W2419844652 @default.
• W2948924404 cites W2474890852 @default.
• W2948924404 cites W2508014140 @default.
• W2948924404 cites W2523315497 @default.
• W2948924404 cites W2546630273 @default.
• W2948924404 cites W2551640496 @default.
• W2948924404 cites W2552997063 @default.
• W2948924404 cites W2558412547 @default.
• W2948924404 cites W2559739670 @default.
• W2948924404 cites W2560424711 @default.
• W2948924404 cites W2561006928 @default.
• W2948924404 cites W2579967741 @default.
• W2948924404 cites W2590308002 @default.
• W2948924404 cites W2593976960 @default.
• W2948924404 cites W2594512116 @default.
• W2948924404 cites W2595424002 @default.
• W2948924404 cites W2601063088 @default.
• W2948924404 cites W2604476397 @default.
• W2948924404 cites W2606332452 @default.
• W2948924404 cites W2614099101 @default.
• W2948924404 cites W2624853583 @default.
• W2948924404 cites W2626592242 @default.
• W2948924404 cites W2705172815 @default.
• W2948924404 cites W2728001011 @default.
• W2948924404 cites W2735543304 @default.

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