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- W2948946304 abstract "Sortase A (SrtA) is an enzyme obtained from Staphylococcus aureus that catalyzes site-specific transpeptidation of surface proteins to the bacterial cell membrane. SrtA recognizes an LPXTG amino acid motif and cleaves between the Thr and Gly to form a thioester-linked acyl–enzyme intermediate. The intermediate is resolved in the presence of a nucleophilic N-terminal polyglycine resulting in ligation of the acyl donor to the polyglycine acceptor. Here we describe the application of SrtA as a tool for the cyclization of disulfide-rich peptides. Reactions are typically tailored to each disulfide-rich peptide with optimal conditions producing yields of 40–50% cyclized peptide." @default.
- W2948946304 created "2019-06-14" @default.
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- W2948946304 date "2019-01-01" @default.
- W2948946304 modified "2023-09-24" @default.
- W2948946304 title "Cyclizing Disulfide-Rich Peptides Using Sortase A" @default.
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- W2948946304 doi "https://doi.org/10.1007/978-1-4939-9546-2_3" @default.
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