Matches in SemOpenAlex for { <https://semopenalex.org/work/W2948956562> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2948956562 abstract "The incidence of Gestational Diabetes Mellitus (GDM) in the world keeps rising, but the detection, diagnosis, and treatment of which are not progressing any further. In the Filipino population, a study showed 14% prevalence of the disease. Among the risk factors associated with GDM are the single nucleotide polymorphisms (SNPs). One of which is melatonin receptor 1B (MTNR1B) particularly, the rs10830963 gene variant. This variant was found to be associated with GDM throughout various populations. With an effort to contribute to the limited existing studies, this research aims to find a correlation of the MTNR1B gene variant rs10830963 with GDM in selected Filipino population. A 75-gram oral glucose tolerance test was performed to confirm GDM among the respondents. DNA extraction of the buffy coat was done using PureLink® Genomic DNA Mini Kit. Purified genomic DNA was genotyped for rs10830963 polymorphism of the MTNR1B gene using Taqman assays (Applied Biosystems). Results showed that homozygous C/C genotype of the rs10830963 gene variant of MTNR1B is negatively correlated with insulin resistance. On the other hand, the heterozygous C/G genotype is correlated with increased level of insulin resistance. Previous study conducted in Korean population concluded that insulin resistance is not associated with this gene variant. Thus, variation in result is present in different populations. Furthermore, the allelic frequencies showed G allele of rs10830963 exhibited a higher level of insulin resistance compared to the C allele. Based on the research of Junior et.al. (2015), the carrier of G allele of rs10830963 is more likely to develop GDM compared to the carrier of C allele of this variant. The rs10830963 gene variant of MTNR1B showed to be a potential risk factor for GDM in selected Filipino Population as the G allele and C/G genotype are significantly correlated with insulin resistance." @default.
- W2948956562 created "2019-06-14" @default.
- W2948956562 creator A5004857067 @default.
- W2948956562 creator A5036889985 @default.
- W2948956562 creator A5046128774 @default.
- W2948956562 creator A5052557084 @default.
- W2948956562 creator A5056108420 @default.
- W2948956562 creator A5065987941 @default.
- W2948956562 creator A5075303882 @default.
- W2948956562 creator A5080385552 @default.
- W2948956562 date "2019-03-25" @default.
- W2948956562 modified "2023-09-27" @default.
- W2948956562 title "RS10830963 GENE VARIANT OF MTNR1B AS A POSSIBLE RISK FACTOR OF GESTATIONAL DIABETES MELLITUS IN SELECTED FILIPINO POPULATION" @default.
- W2948956562 hasPublicationYear "2019" @default.
- W2948956562 type Work @default.
- W2948956562 sameAs 2948956562 @default.
- W2948956562 citedByCount "0" @default.
- W2948956562 crossrefType "journal-article" @default.
- W2948956562 hasAuthorship W2948956562A5004857067 @default.
- W2948956562 hasAuthorship W2948956562A5036889985 @default.
- W2948956562 hasAuthorship W2948956562A5046128774 @default.
- W2948956562 hasAuthorship W2948956562A5052557084 @default.
- W2948956562 hasAuthorship W2948956562A5056108420 @default.
- W2948956562 hasAuthorship W2948956562A5065987941 @default.
- W2948956562 hasAuthorship W2948956562A5075303882 @default.
- W2948956562 hasAuthorship W2948956562A5080385552 @default.
- W2948956562 hasConcept C104317684 @default.
- W2948956562 hasConcept C126322002 @default.
- W2948956562 hasConcept C134018914 @default.
- W2948956562 hasConcept C135763542 @default.
- W2948956562 hasConcept C153209595 @default.
- W2948956562 hasConcept C180754005 @default.
- W2948956562 hasConcept C2777391703 @default.
- W2948956562 hasConcept C2779234561 @default.
- W2948956562 hasConcept C2779434492 @default.
- W2948956562 hasConcept C2908647359 @default.
- W2948956562 hasConcept C37463918 @default.
- W2948956562 hasConcept C46973012 @default.
- W2948956562 hasConcept C54355233 @default.
- W2948956562 hasConcept C555293320 @default.
- W2948956562 hasConcept C71924100 @default.
- W2948956562 hasConcept C86803240 @default.
- W2948956562 hasConcept C99454951 @default.
- W2948956562 hasConceptScore W2948956562C104317684 @default.
- W2948956562 hasConceptScore W2948956562C126322002 @default.
- W2948956562 hasConceptScore W2948956562C134018914 @default.
- W2948956562 hasConceptScore W2948956562C135763542 @default.
- W2948956562 hasConceptScore W2948956562C153209595 @default.
- W2948956562 hasConceptScore W2948956562C180754005 @default.
- W2948956562 hasConceptScore W2948956562C2777391703 @default.
- W2948956562 hasConceptScore W2948956562C2779234561 @default.
- W2948956562 hasConceptScore W2948956562C2779434492 @default.
- W2948956562 hasConceptScore W2948956562C2908647359 @default.
- W2948956562 hasConceptScore W2948956562C37463918 @default.
- W2948956562 hasConceptScore W2948956562C46973012 @default.
- W2948956562 hasConceptScore W2948956562C54355233 @default.
- W2948956562 hasConceptScore W2948956562C555293320 @default.
- W2948956562 hasConceptScore W2948956562C71924100 @default.
- W2948956562 hasConceptScore W2948956562C86803240 @default.
- W2948956562 hasConceptScore W2948956562C99454951 @default.
- W2948956562 hasLocation W29489565621 @default.
- W2948956562 hasOpenAccess W2948956562 @default.
- W2948956562 hasPrimaryLocation W29489565621 @default.
- W2948956562 hasRelatedWork W2084754778 @default.
- W2948956562 hasRelatedWork W2169925136 @default.
- W2948956562 hasRelatedWork W2330185995 @default.
- W2948956562 hasRelatedWork W2366663875 @default.
- W2948956562 hasRelatedWork W2379930704 @default.
- W2948956562 hasRelatedWork W240507305 @default.
- W2948956562 hasRelatedWork W2409382949 @default.
- W2948956562 hasRelatedWork W2414400106 @default.
- W2948956562 hasRelatedWork W2503369196 @default.
- W2948956562 hasRelatedWork W2572481665 @default.
- W2948956562 hasRelatedWork W2598239438 @default.
- W2948956562 hasRelatedWork W2602706882 @default.
- W2948956562 hasRelatedWork W2902329388 @default.
- W2948956562 hasRelatedWork W2945472689 @default.
- W2948956562 hasRelatedWork W3023801719 @default.
- W2948956562 hasRelatedWork W3031846859 @default.
- W2948956562 hasRelatedWork W3081663049 @default.
- W2948956562 hasRelatedWork W3173450099 @default.
- W2948956562 hasRelatedWork W3177307460 @default.
- W2948956562 hasRelatedWork W3171511413 @default.
- W2948956562 isParatext "false" @default.
- W2948956562 isRetracted "false" @default.
- W2948956562 magId "2948956562" @default.
- W2948956562 workType "article" @default.