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- W2948981386 abstract "Secondary hyperparathyroidism (SHPT) relates to high turnover bone loss and is responsible for most bone fractures among chronic kidney disease (CKD) patients. Changes in the Wingless/beta-catenin signaling (Wnt/β-catenin) pathway and Wnt inhibitors have been found to play a critical role in CKD related bone loss. A calcimimetic agent, cinacalcet, is widely used for SHPT and found to be similarly effective for parathyroidectomy clinically. A significant decrease in hip fracture rates is noted among US hemodialysis Medicare patients since 2004, which is probably related to the cinacalcet era. In our previous clinical study, it was proven that cinacalcet improved the bone mineral density (BMD) even among severe SHPT patients. In this study, the influence of cinacalcet use on bone mass among CKD mice was determined. Cinacalcet significantly reduced the cortical porosity in femoral bones of treated CKD mice. It also improved the whole-bone structural properties through increased stiffness and maximum load. Cinacalcet increased femoral bone wingless 10b (Wnt10b) expression in CKD mice. In vitro studies revealed that cinacalcet decreased osteoclast bone resorption and increased Wnt 10b release from osteoclasts. Cinacalcet increased bone mineralization when culturing the osteoblasts with cinacalcet treated osteoclast supernatant. In conclusion, cinacalcet increased bone quantity and quality in CKD mice, probably through increased bone mineralization related with osteoclast Wnt 10b secretion." @default.
- W2948981386 created "2019-06-14" @default.
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- W2948981386 date "2019-06-08" @default.
- W2948981386 modified "2023-09-28" @default.
- W2948981386 title "Osteoclast-Released Wnt-10b Underlies Cinacalcet Related Bone Improvement in Chronic Kidney Disease" @default.
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- W2948981386 cites W191629038 @default.
- W2948981386 cites W1928769707 @default.
- W2948981386 cites W1964059429 @default.
- W2948981386 cites W1966772281 @default.
- W2948981386 cites W1968580734 @default.
- W2948981386 cites W1984199402 @default.
- W2948981386 cites W1987586045 @default.
- W2948981386 cites W1991231767 @default.
- W2948981386 cites W1994288361 @default.
- W2948981386 cites W1994404723 @default.
- W2948981386 cites W1995638940 @default.
- W2948981386 cites W1997839478 @default.
- W2948981386 cites W1998163197 @default.
- W2948981386 cites W2002067415 @default.
- W2948981386 cites W2005828584 @default.
- W2948981386 cites W2016925215 @default.
- W2948981386 cites W2017952509 @default.
- W2948981386 cites W2031481307 @default.
- W2948981386 cites W2036508612 @default.
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- W2948981386 cites W2054323843 @default.
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- W2948981386 cites W2058125623 @default.
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- W2948981386 cites W2086257914 @default.
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- W2948981386 cites W2089610940 @default.
- W2948981386 cites W2099783744 @default.
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- W2948981386 cites W2133574466 @default.
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- W2948981386 cites W2135590648 @default.
- W2948981386 cites W2137070340 @default.
- W2948981386 cites W2141645333 @default.
- W2948981386 cites W2162160942 @default.
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- W2948981386 doi "https://doi.org/10.3390/ijms20112800" @default.
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- W2948981386 hasPublicationYear "2019" @default.
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