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• W2949014700 endingPage "3163" @default.
• W2949014700 startingPage "3141" @default.
• W2949014700 abstract "Abstract Despite vast literature on catecholaminergic neuromodulation of auditory cortex functioning in general, knowledge about its role for long‐term memory formation is scarce. Our previous pharmacological studies on cortex‐dependent frequency‐modulated tone‐sweep discrimination learning of Mongolian gerbils showed that auditory‐cortical D 1/5 ‐dopamine receptor activity facilitates memory consolidation and anterograde memory formation. Considering overlapping functions of D 1/5 ‐dopamine receptors and β‐adrenoceptors, we hypothesised a role of β‐adrenergic signalling in the auditory cortex for sweep discrimination learning and memory. Supporting this hypothesis, the β 1/2 ‐adrenoceptor antagonist propranolol bilaterally applied to the gerbil auditory cortex after task acquisition prevented the discrimination increment that was normally monitored 1 day later. The increment in the total number of hurdle crossings performed in response to the sweeps per se was normal. Propranolol infusion after the seventh training session suppressed the previously established sweep discrimination. The suppressive effect required antagonist injection in a narrow post‐session time window. When applied to the auditory cortex 1 day before initial conditioning, β 1 ‐adrenoceptor‐antagonising and β 1 ‐adrenoceptor‐stimulating agents retarded and facilitated, respectively, sweep discrimination learning, whereas β 2 ‐selective drugs were ineffective. In contrast, single‐sweep detection learning was normal after propranolol infusion. By immunohistochemistry, β 1 ‐ and β 2 ‐adrenoceptors were identified on the neuropil and somata of pyramidal and non‐pyramidal neurons of the gerbil auditory cortex. The present findings suggest that β‐adrenergic signalling in the auditory cortex has task‐related importance for discrimination learning of complex sounds: as previously shown for D 1/5 ‐dopamine receptor signalling, β‐adrenoceptor activity supports long‐term memory consolidation and reconsolidation; additionally, tonic input through β 1 ‐adrenoceptors may control mechanisms permissive for memory acquisition." @default.
• W2949014700 created "2019-06-14" @default.
• W2949014700 creator A5008631938 @default.
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• W2949014700 creator A5087402600 @default.
• W2949014700 creator A5089046528 @default.
• W2949014700 creator A5090724543 @default.
• W2949014700 date "2019-07-01" @default.
• W2949014700 modified "2023-10-16" @default.
• W2949014700 title "β‐adrenergic modulation of discrimination learning and memory in the auditory cortex" @default.
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