Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949014719> ?p ?o ?g. }
- W2949014719 endingPage "577" @default.
- W2949014719 startingPage "559" @default.
- W2949014719 abstract "Abstract A large number of studies have focused on the generation of dopaminergic neurons from pluripotent cells. Differentiation of stem cells into distinct cell types is influenced by tissue‐specific microenvironment. Since, central nervous system undergoes further development during postnatal life, in the present study neonatal rat brain tissue extract (NRBE) was applied to direct the differentiation of embryonal carcinoma stem cell line, P19 into dopaminergic (DA) phenotypes. Additionally, a neuroprotective drug, deprenyl was used alone or in combination with the extract. Results from morphological, immunofluorescence, and qPCR analyses showed that during a period of one to three weeks, a large percentage of stem cells were differentiated into neural cells. The results also indicated the greater effect of NRBE on the differentiation of the cells into tyrosine hydroxylase‐expressing cells. MS analysis of NRBE showed the enrichment of gene ontology terms related to cell differentiation and neurogenesis. Network analysis of the studied genes and some DA markers resulted in the suggestion of potential regulatory candidates such as AVP, ACHE, LHFPL5, and DLK1 genes . In conclusion, NRBE as a natural native inducer was apparently able to simulate the brain microenvironment and support neural differentiation of P19 cells." @default.
- W2949014719 created "2019-06-14" @default.
- W2949014719 creator A5000745307 @default.
- W2949014719 creator A5023962725 @default.
- W2949014719 creator A5049107308 @default.
- W2949014719 creator A5076014632 @default.
- W2949014719 creator A5081190676 @default.
- W2949014719 date "2019-06-01" @default.
- W2949014719 modified "2023-10-16" @default.
- W2949014719 title "Induction of Tyrosine Hydroxylase Gene Expression in Embryonal Carcinoma Stem Cells Using a Natural Tissue‐Specific Inducer" @default.
- W2949014719 cites W1491014419 @default.
- W2949014719 cites W1511587583 @default.
- W2949014719 cites W1521943995 @default.
- W2949014719 cites W1605521640 @default.
- W2949014719 cites W1652680663 @default.
- W2949014719 cites W1888997300 @default.
- W2949014719 cites W1965415058 @default.
- W2949014719 cites W1966918485 @default.
- W2949014719 cites W1973897139 @default.
- W2949014719 cites W1983274440 @default.
- W2949014719 cites W1986656413 @default.
- W2949014719 cites W1990505622 @default.
- W2949014719 cites W1992681202 @default.
- W2949014719 cites W2001565068 @default.
- W2949014719 cites W2002930046 @default.
- W2949014719 cites W2019270281 @default.
- W2949014719 cites W2024167399 @default.
- W2949014719 cites W2029390496 @default.
- W2949014719 cites W2029835962 @default.
- W2949014719 cites W2030851291 @default.
- W2949014719 cites W2033286875 @default.
- W2949014719 cites W2034158287 @default.
- W2949014719 cites W2034821677 @default.
- W2949014719 cites W2036983859 @default.
- W2949014719 cites W2040366241 @default.
- W2949014719 cites W2047961360 @default.
- W2949014719 cites W2051804874 @default.
- W2949014719 cites W2053544091 @default.
- W2949014719 cites W2055593778 @default.
- W2949014719 cites W2056413798 @default.
- W2949014719 cites W2060071458 @default.
- W2949014719 cites W2061185374 @default.
- W2949014719 cites W2064502520 @default.
- W2949014719 cites W2066162239 @default.
- W2949014719 cites W2068412840 @default.
- W2949014719 cites W2068780842 @default.
- W2949014719 cites W2069469650 @default.
- W2949014719 cites W2075643547 @default.
- W2949014719 cites W2077212426 @default.
- W2949014719 cites W2080752012 @default.
- W2949014719 cites W2080875310 @default.
- W2949014719 cites W2096139472 @default.
- W2949014719 cites W2101891297 @default.
- W2949014719 cites W2103493168 @default.
- W2949014719 cites W2104793567 @default.
- W2949014719 cites W2106061238 @default.
- W2949014719 cites W2106829291 @default.
- W2949014719 cites W2114918609 @default.
- W2949014719 cites W2119936622 @default.
- W2949014719 cites W2122191105 @default.
- W2949014719 cites W2135668873 @default.
- W2949014719 cites W2143965041 @default.
- W2949014719 cites W2147015050 @default.
- W2949014719 cites W2152200638 @default.
- W2949014719 cites W2153754104 @default.
- W2949014719 cites W2154044387 @default.
- W2949014719 cites W2159675211 @default.
- W2949014719 cites W2167908407 @default.
- W2949014719 cites W2189537773 @default.
- W2949014719 cites W2279488356 @default.
- W2949014719 cites W2462216989 @default.
- W2949014719 cites W2488055047 @default.
- W2949014719 cites W2808234414 @default.
- W2949014719 cites W2903365961 @default.
- W2949014719 doi "https://doi.org/10.1002/dneu.22703" @default.
- W2949014719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31177638" @default.
- W2949014719 hasPublicationYear "2019" @default.
- W2949014719 type Work @default.
- W2949014719 sameAs 2949014719 @default.
- W2949014719 citedByCount "3" @default.
- W2949014719 countsByYear W29490147192022 @default.
- W2949014719 crossrefType "journal-article" @default.
- W2949014719 hasAuthorship W2949014719A5000745307 @default.
- W2949014719 hasAuthorship W2949014719A5023962725 @default.
- W2949014719 hasAuthorship W2949014719A5049107308 @default.
- W2949014719 hasAuthorship W2949014719A5076014632 @default.
- W2949014719 hasAuthorship W2949014719A5081190676 @default.
- W2949014719 hasConcept C104317684 @default.
- W2949014719 hasConcept C107459253 @default.
- W2949014719 hasConcept C136834591 @default.
- W2949014719 hasConcept C145103041 @default.
- W2949014719 hasConcept C148738053 @default.
- W2949014719 hasConcept C159167319 @default.
- W2949014719 hasConcept C169760540 @default.
- W2949014719 hasConcept C20875687 @default.
- W2949014719 hasConcept C26805974 @default.
- W2949014719 hasConcept C2780327976 @default.
- W2949014719 hasConcept C28328180 @default.