FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949029539> ?p ?o ?g. }

• W2949029539 endingPage "e000985" @default.
• W2949029539 startingPage "e000985" @default.
• W2949029539 abstract "Background In Fontan patients with atrial arrhythmias (AA), non-vitamin K antagonist oral anticoagulants(NOACs) have a class III recommendation according to the Pediatric & Congenital Electrophysiology Society (PACES)/Heart Rhythm Society (HRS) guideline in 2014, due to lack of data on outcomes as opposed to evidence of harm. To address this gap in data, we investigated the safety and efficacy of NOACs in adults with a Fontan circulation in a worldwide study. Methods This is an international multicentre prospective cohort study, using data from the NOTE ( n on-vitamin K antagonist o ral anticoagulants for t hrombo e mbolic prevention in patients with congenital heart disease) registry. The study population comprised consecutive adults with a Fontan circulation using NOACs. Follow-up took place at 6 months and yearly thereafter. The primary endpoints were thromboembolism and major bleeding. Secondary endpoint was minor bleeding. Results From April 2014 onward, 74 patients (mean age 32±10 years (range 18–68), 54% male) with a Fontan circulation using NOACs were included. During a median follow-up of 1.2 (IQR 0.8–2.0) years, three thromboembolic events (2.9 per 100 patient-years (95% CI 0.7 to 7.6)) and three major bleedings (2.9 per 100 patient-years (95% CI 0.7 to 7.6)) occurred in five atriopulmonary Fontan and one total cavopulmonary connection Fontan patients with AA. Fifteen patients experienced minor bleeding episodes (15.8 per 100 patient-years (95% CI 9.1 to 25.2)). In patients (n=37) using vitamin K antagonists (VKAs) prior to the initiation of NOAC, annual incidence of historical thromboembolic events and major bleeding were 2.4% (95% CI 0.4% to 7.4%) (n = 2) and 1.2% (95% CI 0.7% to 5.1%) (n = 1), respectively. Conclusions In this review of the largest Fontan cohort using NOACs with prospective follow-up, NOACs appear to be well tolerated and their efficacy and safety during short-term follow-up seem comparable to VKAs. Longer term data are required to confirm these promising short-term results." @default.
• W2949029539 created "2019-06-14" @default.
• W2949029539 creator A5001228729 @default.
• W2949029539 creator A5001618823 @default.
• W2949029539 creator A5016532880 @default.
• W2949029539 creator A5018563580 @default.
• W2949029539 creator A5023376221 @default.
• W2949029539 creator A5028476008 @default.
• W2949029539 creator A5034635968 @default.
• W2949029539 creator A5038035746 @default.
• W2949029539 creator A5038978714 @default.
• W2949029539 creator A5039535360 @default.
• W2949029539 creator A5042270891 @default.
• W2949029539 creator A5043968030 @default.
• W2949029539 creator A5047059084 @default.
• W2949029539 creator A5061999743 @default.
• W2949029539 creator A5065887068 @default.
• W2949029539 creator A5066085574 @default.
• W2949029539 creator A5073538187 @default.
• W2949029539 creator A5073792281 @default.
• W2949029539 creator A5076337803 @default.
• W2949029539 date "2019-06-01" @default.
• W2949029539 modified "2023-10-06" @default.
• W2949029539 title "Non-vitamin K antagonist oral anticoagulants in adults with a Fontan circulation: are they safe" @default.
• W2949029539 cites W1505239733 @default.
• W2949029539 cites W1985180981 @default.
• W2949029539 cites W1993016197 @default.
• W2949029539 cites W2001057711 @default.
• W2949029539 cites W2057192740 @default.
• W2949029539 cites W2057448559 @default.
• W2949029539 cites W2072154801 @default.
• W2949029539 cites W2142333882 @default.
• W2949029539 cites W2287009094 @default.
• W2949029539 cites W2525052087 @default.
• W2949029539 cites W2529569613 @default.
• W2949029539 cites W2607149163 @default.
• W2949029539 cites W2742514347 @default.
• W2949029539 cites W2791321998 @default.
• W2949029539 doi "https://doi.org/10.1136/openhrt-2018-000985" @default.
• W2949029539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6560660" @default.
• W2949029539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31245011" @default.
• W2949029539 hasPublicationYear "2019" @default.
• W2949029539 type Work @default.
• W2949029539 sameAs 2949029539 @default.
• W2949029539 citedByCount "22" @default.
• W2949029539 countsByYear W29490295392020 @default.
• W2949029539 countsByYear W29490295392021 @default.
• W2949029539 countsByYear W29490295392022 @default.
• W2949029539 countsByYear W29490295392023 @default.
• W2949029539 crossrefType "journal-article" @default.
• W2949029539 hasAuthorship W2949029539A5001228729 @default.
• W2949029539 hasAuthorship W2949029539A5001618823 @default.
• W2949029539 hasAuthorship W2949029539A5016532880 @default.
• W2949029539 hasAuthorship W2949029539A5018563580 @default.
• W2949029539 hasAuthorship W2949029539A5023376221 @default.
• W2949029539 hasAuthorship W2949029539A5028476008 @default.
• W2949029539 hasAuthorship W2949029539A5034635968 @default.
• W2949029539 hasAuthorship W2949029539A5038035746 @default.
• W2949029539 hasAuthorship W2949029539A5038978714 @default.
• W2949029539 hasAuthorship W2949029539A5039535360 @default.
• W2949029539 hasAuthorship W2949029539A5042270891 @default.
• W2949029539 hasAuthorship W2949029539A5043968030 @default.
• W2949029539 hasAuthorship W2949029539A5047059084 @default.
• W2949029539 hasAuthorship W2949029539A5061999743 @default.
• W2949029539 hasAuthorship W2949029539A5065887068 @default.
• W2949029539 hasAuthorship W2949029539A5066085574 @default.
• W2949029539 hasAuthorship W2949029539A5073538187 @default.
• W2949029539 hasAuthorship W2949029539A5073792281 @default.
• W2949029539 hasAuthorship W2949029539A5076337803 @default.
• W2949029539 hasBestOaLocation W29490295391 @default.
• W2949029539 hasConcept C126322002 @default.
• W2949029539 hasConcept C141071460 @default.
• W2949029539 hasConcept C164705383 @default.
• W2949029539 hasConcept C187212893 @default.
• W2949029539 hasConcept C2776301958 @default.
• W2949029539 hasConcept C2776704044 @default.
• W2949029539 hasConcept C2776974648 @default.
• W2949029539 hasConcept C2779161974 @default.
• W2949029539 hasConcept C2780074459 @default.
• W2949029539 hasConcept C2908647359 @default.
• W2949029539 hasConcept C71924100 @default.
• W2949029539 hasConcept C72563966 @default.
• W2949029539 hasConcept C99454951 @default.
• W2949029539 hasConceptScore W2949029539C126322002 @default.
• W2949029539 hasConceptScore W2949029539C141071460 @default.
• W2949029539 hasConceptScore W2949029539C164705383 @default.
• W2949029539 hasConceptScore W2949029539C187212893 @default.
• W2949029539 hasConceptScore W2949029539C2776301958 @default.
• W2949029539 hasConceptScore W2949029539C2776704044 @default.
• W2949029539 hasConceptScore W2949029539C2776974648 @default.
• W2949029539 hasConceptScore W2949029539C2779161974 @default.
• W2949029539 hasConceptScore W2949029539C2780074459 @default.
• W2949029539 hasConceptScore W2949029539C2908647359 @default.
• W2949029539 hasConceptScore W2949029539C71924100 @default.
• W2949029539 hasConceptScore W2949029539C72563966 @default.
• W2949029539 hasConceptScore W2949029539C99454951 @default.
• W2949029539 hasFunder F4320306257 @default.
• W2949029539 hasFunder F4320307115 @default.

• next