Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949031805> ?p ?o ?g. }
- W2949031805 endingPage "356" @default.
- W2949031805 startingPage "356" @default.
- W2949031805 abstract "Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for both normal development and numerous pathologies. Systems biology has offered a unique approach to study angiogenesis by profiling tyrosine kinase receptors (RTKs) that regulate angiogenic processes and computationally modeling RTK signaling pathways. Historically, this systems biology approach has been applied on ex vivo angiogenesis assays, however, these assays are difficult to quantify and limited in their potential of temporal analysis. In this study, we adopted a simple two-dimensional angiogenesis assay comprised of human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) and examined temporal dynamics of a panel of six RTKs and cell heterogeneity up to 17 days. We observed ~2700 VEGFR1 (vascular endothelial growth factor receptor 1) per cell on 24-h-old cocultured HDF plasma membranes, which do not express VEGFR when cultured alone. We observed 4000–8100 VEGFR2 per cell on cocultured HUVEC plasma membranes throughout endothelial tube formation. We showed steady increase of platelet-derived growth factor receptors (PDGFRs) on cocultured HDF plasma membranes, and more interestingly, 1900–2900 PDGFRβ per plasma membrane were found on HUVECs within the first six hours of coculturing. These quantitative findings will offer us insights into molecular regulation during angiogenesis and help assess in vitro tube formation models and their physiological relevance." @default.
- W2949031805 created "2019-06-14" @default.
- W2949031805 creator A5052367381 @default.
- W2949031805 creator A5066755382 @default.
- W2949031805 date "2019-06-10" @default.
- W2949031805 modified "2023-09-25" @default.
- W2949031805 title "Single-Cell Receptor Quantification of an In Vitro Coculture Angiogenesis Model Reveals VEGFR, NRP1, Tie2, and PDGFR Regulation and Endothelial Heterogeneity" @default.
- W2949031805 cites W1516603921 @default.
- W2949031805 cites W1551620887 @default.
- W2949031805 cites W1561178184 @default.
- W2949031805 cites W1572267828 @default.
- W2949031805 cites W1584607924 @default.
- W2949031805 cites W1600721209 @default.
- W2949031805 cites W1664379753 @default.
- W2949031805 cites W1878663564 @default.
- W2949031805 cites W1970606334 @default.
- W2949031805 cites W1972344356 @default.
- W2949031805 cites W1977999028 @default.
- W2949031805 cites W1978139448 @default.
- W2949031805 cites W1979356105 @default.
- W2949031805 cites W1981030985 @default.
- W2949031805 cites W1982486040 @default.
- W2949031805 cites W1982912692 @default.
- W2949031805 cites W1988864250 @default.
- W2949031805 cites W1990368500 @default.
- W2949031805 cites W1995031555 @default.
- W2949031805 cites W1995592923 @default.
- W2949031805 cites W1996644698 @default.
- W2949031805 cites W1997508706 @default.
- W2949031805 cites W1997796989 @default.
- W2949031805 cites W2007811308 @default.
- W2949031805 cites W2012390831 @default.
- W2949031805 cites W2012576713 @default.
- W2949031805 cites W2020089786 @default.
- W2949031805 cites W2020699253 @default.
- W2949031805 cites W2023848963 @default.
- W2949031805 cites W2029698856 @default.
- W2949031805 cites W2033049522 @default.
- W2949031805 cites W2033651825 @default.
- W2949031805 cites W2036027118 @default.
- W2949031805 cites W2038408091 @default.
- W2949031805 cites W2049265952 @default.
- W2949031805 cites W2050323086 @default.
- W2949031805 cites W2053221827 @default.
- W2949031805 cites W2053547715 @default.
- W2949031805 cites W2057280160 @default.
- W2949031805 cites W2061078277 @default.
- W2949031805 cites W2065284939 @default.
- W2949031805 cites W2069312048 @default.
- W2949031805 cites W2073290778 @default.
- W2949031805 cites W2077122323 @default.
- W2949031805 cites W2079841959 @default.
- W2949031805 cites W2080162976 @default.
- W2949031805 cites W2081399416 @default.
- W2949031805 cites W2084942072 @default.
- W2949031805 cites W2086272423 @default.
- W2949031805 cites W2087271480 @default.
- W2949031805 cites W2088039946 @default.
- W2949031805 cites W2090882698 @default.
- W2949031805 cites W2091774189 @default.
- W2949031805 cites W2092074451 @default.
- W2949031805 cites W2094406330 @default.
- W2949031805 cites W2094891612 @default.
- W2949031805 cites W2099194598 @default.
- W2949031805 cites W2100454247 @default.
- W2949031805 cites W2102578228 @default.
- W2949031805 cites W2107583561 @default.
- W2949031805 cites W2108970605 @default.
- W2949031805 cites W2109134893 @default.
- W2949031805 cites W2112251383 @default.
- W2949031805 cites W2112940666 @default.
- W2949031805 cites W2119488021 @default.
- W2949031805 cites W2120895512 @default.
- W2949031805 cites W2122818908 @default.
- W2949031805 cites W2123340693 @default.
- W2949031805 cites W2124143152 @default.
- W2949031805 cites W2126187296 @default.
- W2949031805 cites W2129802470 @default.
- W2949031805 cites W2135747342 @default.
- W2949031805 cites W2139731074 @default.
- W2949031805 cites W2147276811 @default.
- W2949031805 cites W2148371225 @default.
- W2949031805 cites W2151752381 @default.
- W2949031805 cites W2155214429 @default.
- W2949031805 cites W2156324629 @default.
- W2949031805 cites W2156606731 @default.
- W2949031805 cites W2160342295 @default.
- W2949031805 cites W2169199162 @default.
- W2949031805 cites W2196685142 @default.
- W2949031805 cites W2229729310 @default.
- W2949031805 cites W2248179576 @default.
- W2949031805 cites W2589355202 @default.
- W2949031805 cites W2747863777 @default.
- W2949031805 cites W2771551779 @default.
- W2949031805 cites W2803326208 @default.
- W2949031805 cites W2810826217 @default.
- W2949031805 cites W4238601639 @default.
- W2949031805 cites W4253705647 @default.