FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2949032010> ?p ?o ?g. }

• W2949032010 endingPage "1239" @default.
• W2949032010 startingPage "1229" @default.
• W2949032010 abstract "Abstract 1p/19q codeletion, which leads to the abnormal expression of 1p19q genes in oligodendroglioma, is associated with chemosensitivity and favorable prognosis. Here, we aimed to explore the clinical implications of 1p19q gene expression in 1p/19q non-codel gliomas. We analyzed expression of 1p19q genes in 668 1p/19q non-codel gliomas obtained from The Cancer Genome Atlas (n = 447) and the Chinese Glioma Genome Atlas (n = 221) for training and validation, respectively. The expression of 1p19q genes was significantly correlated with the clinicopathological features and overall survival of 1p/19q non-codel gliomas. Then, we derived a risk signature of 25 selected 1p19q genes that not only had prognosis value in total 1p/19q non-codel gliomas but also had prognosis value in stratified gliomas. The prognosis value of the risk signature was superior than known clinicopathological features in 1p/19q non-codel gliomas and was also highly associated with the following features: loss of CDKN2A/B copy number in mutant-IDH-astrocytoma; telomerase reverse transcriptase (TERT) promoter mutation, combined chromosome 7 gain/chromosome 10 loss and epidermal growth factor receptor amplification in wild-type-IDH-astrocytoma; classical and mesenchymal subtypes in glioblastoma. Furthermore, genes enriched in the biological processes of cell division, extracellular matrix, angiogenesis significantly correlated to the signature risk score, and this is also supported by the immunohistochemistry and cell biology experiments. In conclusion, the expression profile of 1p19q genes is highly associated with the malignancy and prognosis of 1p/19q non-codel gliomas. A 25-1p19q-gene signature has powerfully predictive value for both malignant molecular pathological features and prognosis across distinct subgroups of 1p/19q non-codel gliomas." @default.
• W2949032010 created "2019-06-14" @default.
• W2949032010 creator A5001711651 @default.
• W2949032010 creator A5010406647 @default.
• W2949032010 creator A5058058959 @default.
• W2949032010 creator A5060887873 @default.
• W2949032010 creator A5070697945 @default.
• W2949032010 creator A5074695215 @default.
• W2949032010 creator A5080893365 @default.
• W2949032010 creator A5082515921 @default.
• W2949032010 creator A5087648864 @default.
• W2949032010 creator A5089111537 @default.
• W2949032010 date "2019-06-03" @default.
• W2949032010 modified "2023-10-16" @default.
• W2949032010 title "Systematically characterize the clinical and biological significances of 1p19q genes in 1p/19q non-codeletion glioma" @default.
• W2949032010 cites W1812256879 @default.
• W2949032010 cites W2001493754 @default.
• W2949032010 cites W2008721015 @default.
• W2949032010 cites W2012339972 @default.
• W2949032010 cites W2042681244 @default.
• W2949032010 cites W2078116811 @default.
• W2949032010 cites W2102027775 @default.
• W2949032010 cites W2110700778 @default.
• W2949032010 cites W2128130529 @default.
• W2949032010 cites W2149840758 @default.
• W2949032010 cites W2160687134 @default.
• W2949032010 cites W2166552850 @default.
• W2949032010 cites W2168051713 @default.
• W2949032010 cites W2170000375 @default.
• W2949032010 cites W2263206910 @default.
• W2949032010 cites W2295059886 @default.
• W2949032010 cites W2296309800 @default.
• W2949032010 cites W2313086999 @default.
• W2949032010 cites W2336375427 @default.
• W2949032010 cites W2366536035 @default.
• W2949032010 cites W2592397787 @default.
• W2949032010 cites W2593604059 @default.
• W2949032010 cites W2608192684 @default.
• W2949032010 cites W2620446315 @default.
• W2949032010 cites W2738595852 @default.
• W2949032010 cites W2739147644 @default.
• W2949032010 cites W2739998491 @default.
• W2949032010 cites W2767187153 @default.
• W2949032010 cites W2782139737 @default.
• W2949032010 cites W2790268936 @default.
• W2949032010 cites W2790652961 @default.
• W2949032010 cites W2791767827 @default.
• W2949032010 cites W2793839551 @default.
• W2949032010 cites W2801609626 @default.
• W2949032010 cites W2802491296 @default.
• W2949032010 cites W2802635347 @default.
• W2949032010 cites W2802818144 @default.
• W2949032010 cites W2809591850 @default.
• W2949032010 cites W2894102714 @default.
• W2949032010 cites W2895493353 @default.
• W2949032010 cites W2900435996 @default.
• W2949032010 cites W2911890835 @default.
• W2949032010 cites W2917441328 @default.
• W2949032010 cites W571060166 @default.
• W2949032010 doi "https://doi.org/10.1093/carcin/bgz102" @default.
• W2949032010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31157866" @default.
• W2949032010 hasPublicationYear "2019" @default.
• W2949032010 type Work @default.
• W2949032010 sameAs 2949032010 @default.
• W2949032010 citedByCount "41" @default.
• W2949032010 countsByYear W29490320102019 @default.
• W2949032010 countsByYear W29490320102020 @default.
• W2949032010 countsByYear W29490320102021 @default.
• W2949032010 countsByYear W29490320102022 @default.
• W2949032010 countsByYear W29490320102023 @default.
• W2949032010 crossrefType "journal-article" @default.
• W2949032010 hasAuthorship W2949032010A5001711651 @default.
• W2949032010 hasAuthorship W2949032010A5010406647 @default.
• W2949032010 hasAuthorship W2949032010A5058058959 @default.
• W2949032010 hasAuthorship W2949032010A5060887873 @default.
• W2949032010 hasAuthorship W2949032010A5070697945 @default.
• W2949032010 hasAuthorship W2949032010A5074695215 @default.
• W2949032010 hasAuthorship W2949032010A5080893365 @default.
• W2949032010 hasAuthorship W2949032010A5082515921 @default.
• W2949032010 hasAuthorship W2949032010A5087648864 @default.
• W2949032010 hasAuthorship W2949032010A5089111537 @default.
• W2949032010 hasConcept C121608353 @default.
• W2949032010 hasConcept C126322002 @default.
• W2949032010 hasConcept C142724271 @default.
• W2949032010 hasConcept C143998085 @default.
• W2949032010 hasConcept C2777931997 @default.
• W2949032010 hasConcept C2778227246 @default.
• W2949032010 hasConcept C2778880634 @default.
• W2949032010 hasConcept C2780265364 @default.
• W2949032010 hasConcept C2910969760 @default.
• W2949032010 hasConcept C502942594 @default.
• W2949032010 hasConcept C71924100 @default.
• W2949032010 hasConcept C86803240 @default.
• W2949032010 hasConceptScore W2949032010C121608353 @default.
• W2949032010 hasConceptScore W2949032010C126322002 @default.
• W2949032010 hasConceptScore W2949032010C142724271 @default.
• W2949032010 hasConceptScore W2949032010C143998085 @default.
• W2949032010 hasConceptScore W2949032010C2777931997 @default.

• next