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• W2949125436 abstract "Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic drug development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are supposed to mimic. Aging dogs not only naturally develop a cognitive decline in many aspects including learning and memory deficits, but they also exhibit human-like individual variability in the aging process. Neurodegenerative processes that can be observed in both human and canine brains include the progressive accumulation of β-amyloid (Aβ) found as diffuse plaques in the prefrontal cortex (PFC), including the gyrus proreus (i.e., medial orbital PFC), as well as the hippocampus and the cerebral vasculature. Tau pathology, a marker of neurodegeneration and dementia progression, was also found in canine hippocampal synapses. Various epidemiological data show that human patients with neurodegenerative diseases have concurrent intestinal lesions, and histopathological changes in the gastrointestinal (GI) tract occurs decades before neurodegenerative changes. Gut microbiome alterations have also been reported in many neurodegenerative diseases including Alzheimer's (AD) and Parkinson's diseases, as well as inflammatory central nervous system (CNS) diseases. Interestingly, the dog gut microbiome more closely resembles human gut microbiome in composition and functional overlap compared to rodent models. This article reviews the physiology of the gut-brain axis (GBA) and its involvement with neurodegenerative diseases in humans. Additionally, we outline the advantages and weaknesses of current in vitro and in vivo models and discuss future research directions investigating major human neurodegenerative diseases such as AD and Parkinson's diseases using dogs." @default.
• W2949125436 created "2019-06-27" @default.
• W2949125436 creator A5028552606 @default.
• W2949125436 creator A5028563213 @default.
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• W2949125436 creator A5044852582 @default.
• W2949125436 creator A5052668077 @default.
• W2949125436 creator A5062945808 @default.
• W2949125436 creator A5073384154 @default.
• W2949125436 date "2019-06-18" @default.
• W2949125436 modified "2023-10-17" @default.
• W2949125436 title "The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review" @default.
• W2949125436 cites W1487645896 @default.
• W2949125436 cites W1489339892 @default.
• W2949125436 cites W1526611045 @default.
• W2949125436 cites W1537685484 @default.
• W2949125436 cites W1562824548 @default.
• W2949125436 cites W157594748 @default.
• W2949125436 cites W1582304017 @default.
• W2949125436 cites W1603652592 @default.
• W2949125436 cites W1663623302 @default.
• W2949125436 cites W1759131233 @default.
• W2949125436 cites W1855414735 @default.
• W2949125436 cites W1895993106 @default.
• W2949125436 cites W1897859562 @default.
• W2949125436 cites W1934236512 @default.
• W2949125436 cites W1965670935 @default.
• W2949125436 cites W1970308163 @default.
• W2949125436 cites W1971639265 @default.
• W2949125436 cites W1976118863 @default.
• W2949125436 cites W1977444960 @default.
• W2949125436 cites W1977682751 @default.
• W2949125436 cites W1979221664 @default.
• W2949125436 cites W1982535961 @default.
• W2949125436 cites W1983479692 @default.
• W2949125436 cites W1983564695 @default.
• W2949125436 cites W1985656429 @default.
• W2949125436 cites W1986322653 @default.
• W2949125436 cites W1987744512 @default.
• W2949125436 cites W1991038037 @default.
• W2949125436 cites W1994102478 @default.
• W2949125436 cites W1995023151 @default.
• W2949125436 cites W1995417833 @default.
• W2949125436 cites W1996151441 @default.
• W2949125436 cites W1997114875 @default.
• W2949125436 cites W1997326200 @default.
• W2949125436 cites W1999937803 @default.
• W2949125436 cites W2000777408 @default.
• W2949125436 cites W2007580616 @default.
• W2949125436 cites W2013322269 @default.
• W2949125436 cites W2020460747 @default.
• W2949125436 cites W2025411649 @default.
• W2949125436 cites W2031136972 @default.
• W2949125436 cites W2031431575 @default.
• W2949125436 cites W2032004007 @default.
• W2949125436 cites W2032684594 @default.
• W2949125436 cites W2033085346 @default.
• W2949125436 cites W2033571021 @default.
• W2949125436 cites W2034466802 @default.
• W2949125436 cites W2035204299 @default.
• W2949125436 cites W2038213284 @default.
• W2949125436 cites W2039029682 @default.
• W2949125436 cites W2042045396 @default.
• W2949125436 cites W2042966900 @default.
• W2949125436 cites W2043274894 @default.
• W2949125436 cites W2045508263 @default.
• W2949125436 cites W2046202110 @default.
• W2949125436 cites W2047301149 @default.
• W2949125436 cites W2048897966 @default.
• W2949125436 cites W2057998085 @default.
• W2949125436 cites W2058697507 @default.
• W2949125436 cites W2061549861 @default.
• W2949125436 cites W2063894419 @default.
• W2949125436 cites W2066059566 @default.
• W2949125436 cites W2076087096 @default.
• W2949125436 cites W2080242803 @default.
• W2949125436 cites W2081135553 @default.
• W2949125436 cites W2084026183 @default.
• W2949125436 cites W2084256007 @default.
• W2949125436 cites W2085146964 @default.
• W2949125436 cites W2087741302 @default.
• W2949125436 cites W2088662726 @default.
• W2949125436 cites W2088965395 @default.
• W2949125436 cites W2096036520 @default.
• W2949125436 cites W2096565553 @default.
• W2949125436 cites W2096769476 @default.
• W2949125436 cites W2099594801 @default.
• W2949125436 cites W2100529170 @default.
• W2949125436 cites W2102669626 @default.
• W2949125436 cites W2103939473 @default.
• W2949125436 cites W2104209550 @default.
• W2949125436 cites W2104233691 @default.
• W2949125436 cites W2105036397 @default.
• W2949125436 cites W2106798170 @default.
• W2949125436 cites W2107527993 @default.
• W2949125436 cites W2111438011 @default.
• W2949125436 cites W2112874908 @default.
• W2949125436 cites W2117581926 @default.
• W2949125436 cites W2122827512 @default.

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