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• W2949144482 abstract "Summary blurb m 6 A-modification in the 5’ vicinity of the coding sequence of transcripts provides a selective mechanism for triaging mRNAs to stress granules and is mediated by YTHDF3 ‘reader’ protein. Abstract Reversible post-transcriptional modifications on messenger RNA emerge as prevalent phenomena in RNA metabolism. The most abundant among them is N 6 -methyladenosine (m 6 A) which is pivotal for RNA metabolism and function, its role in stress response remains elusive. We have discovered that in response to oxidative stress, transcripts are additionally m 6 A-modified in their 5’ vicinity. Distinct from that of the translationally-active mRNAs, this methylation pattern provides a selective mechanism for triaging mRNAs from the translatable pool to stress-induced stress granules. These stress-induced newly methylated sites are selectively recognized by the YTH domain family 3 (YTHDF3) ‘reader’ protein, thereby revealing a new role for YTHDF3 in shaping the selectivity of stress response. Our findings describe a previously unappreciated function for RNA m 6 A modification in the oxidative-stress response and expand the breadth of physiological roles of m 6 A." @default.
• W2949144482 created "2019-06-27" @default.
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• W2949144482 date "2018-06-27" @default.
• W2949144482 modified "2023-09-27" @default.
• W2949144482 title "Dynamic m6A methylation facilitates mRNA triaging to stress granules" @default.
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• W2949144482 doi "https://doi.org/10.1101/357012" @default.
• W2949144482 hasPublicationYear "2018" @default.
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